Evidence map›Paper›PMID 39601564›Full record

ArticlemBio2025

Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors.

Xiujuan Zhang, Siyuan Hao, Zehua Feng, Kang Ning, Cagla Aksu Kuz, Shane McFarlin, Donovan Richart, Fang Cheng, Ander Zhang-Chen, Richenda McFarlane and 2 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Xiujuan ZhangDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0009-0007-4268-4171
Siyuan HaoDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Zehua FengDepartment of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA.
Kang NingDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Cagla Aksu KuzDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0009-0001-6216-9077
Shane McFarlinDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Donovan RichartDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Fang ChengDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Ander Zhang-ChenGeneGoCell Inc., San Diego, California, USA.
Richenda McFarlaneGeneGoCell Inc., San Diego, California, USA.
Ziying YanDepartment of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-8210-5567
Jianming QiuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0001-9850-1695

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Novel Approaches for the Control of Microbial PathogensP30GM103326 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LUTKENHAUS, JOSEPH F · 2012 to 2016
$5.3M
Viral and Host Determinants of Parvovirus ReplicationR01AI150877 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2020 to 2024
$2.4M
Development of novel approaches for gene editing therapies of cystic fibrosisR01HL174593 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jianming Qiu, Ziying Yan · 2024 to 2026
$1.9M
Super resolution microscope for the imaging core facilityS10OD023625 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NISHIMUNE, HIROSHI · 2019 to 2019
$987k
Spinning-Disk Confocal Microscope for Wide-Field, Super-Resolution, and Live-Cell ImagingS10OD032207 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2022 to 2022
$600k
Development of a Novel rAAV Vector Without Cross-species Barrier to Transduce Human and Ferret Conducting AirwaysR21AI156448 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING, YAN, ZIYING · 2021 to 2022
$438k
Identification of the AAVR-independent AAV entry pathwayR21AI166293 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2021 to 2022
$425k
Studies of the KIAA0319L-mediated productive transduction pathways of rAAV vectorsR21AI180416 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2024 to 2025
$419k
Cystic Fibrosis Foundation (CFF) YAN23G0HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL174593HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI150877HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI156448HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI166293HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI180416NCI NIH HHS P30 CA168524NHLBI NIH HHS R01 HL174593NIAID NIH HHS R01 AI150877NIAID NIH HHS R21 AI156448NIAID NIH HHS R21 AI166293NIAID NIH HHS R21 AI180416NIGMS NIH HHS P30 GM103326NIH HHS S10 OD023625NIH HHS S10 OD032207
6 · The paper itself

Abstract

We conducted a genome-wide CRISPR/Cas9 screen in suspension 293 F cells transduced with rAAV5. The highly selected genes revealed after two rounds of screening included the previously reported

Indexed as

DependovirusGenetic VectorsNucleotide Transport ProteinsTransduction, GeneticCRISPR-Cas SystemsGene Knockout TechniquesGolgi ApparatusHEK293 CellsHumansSerogroupNucleotide Transport ProteinsSLC35A1 protein, humanintracellular traffickingnuclear importrAAVSLC35A1transduction

Identifiers

PMID39601564
PMCPMC11708056

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.