Evidence map›Paper›PMID 39601345›Full record

ArticlePharmacotherapy2024

Challenges in renally eliminated medication use: Evaluating cystatin C and serum creatinine eGFR discordance.

Brandy N Hernandez, Patrick M Wieruszewski, Jason N Barreto, Kristin C Cole, Shivam Damani, Sandra L Kane-Gill, Kianoush B Kashani, Ellen Kelly, Andrew D Rule, Hilary R Teaford and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Pharmacotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brandy N HernandezDepartment of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.
Patrick M WieruszewskiDepartment of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-5871-5186
Jason N BarretoDepartment of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-2146-5766
Kristin C ColeDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Shivam DamaniDepartment of Medicine AI and Innovation, Mayo Clinic, Rochester, Minnesota, USA.
Sandra L Kane-GillDepartment of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kianoush B KashaniDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Ellen KellyDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Andrew D RuleDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Hilary R TeafordDepartment of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.
Jaleh ZandDepartment of Medicine AI and Innovation, Mayo Clinic, Rochester, Minnesota, USA.
Erin F BarretoDepartment of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-0996-1487

Funding

Pharmacology CoreU54AT008909 · NCCIH · WASHINGTON STATE UNIVERSITY · PI BOYCE, RICHARD DAVID · 2015 to 2024
$22.4M
The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC)-SupplementU01DK130010 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kaleab Z Abebe, LINDA Faith FRIED · 2021 to 2026
$6.1M
(MEnD-AKI) Multicenter Implementation of an Electronic Decision Support System for Drug-associated AKIR01DK121730 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIHORAC, AZRA, KANE-GILL, SANDRA L · 2021 to 2025
$3.2M
Beta-lactam individualization for critically ill patientsK23AI143882 · NIAID · MAYO CLINIC ROCHESTER · PI BARRETO, ERIN FRAZEE · 2020 to 2024
$986k
NCCIH NIH HHS U54 AT008909NIAID NIH HHS K23 AI143882NIDDK NIH HHS R01 DK121730NIDDK NIH HHS U01 DK130010NIH HHS
6 · The paper itself

Abstract

backgroundAccurately estimating glomerular filtration rate (GFR) is crucial for dosing medications in hospitalized patients. Due to limitations of serum creatinine for GFR estimation, serum cystatin C (CysC) has been explored as an alternative functional kidney biomarker. This study assessed discordance between eGFR

methodsThis multisite historical study included adults hospitalized between 2011 and 2023 with CysC and serum creatinine reported within 24 h of each other. The first concurrent biomarker pair for each patient was analyzed. eGFR discordance and use of renally eliminated medications were described.

results17,718 hospitalized patients with concurrent creatinine and CysC assessments were included. The median eGFR

conclusionSubstantial eGFR discordance between eGFR

Indexed as

BiomarkersCreatinineCystatin CGlomerular Filtration RateAdultAgedAged, 80 and overFemaleHospitalizationHumansMaleMiddle AgedBiomarkersCreatinineCystatin Cdiscordanceglomerular filtration ratemedication safetyrenally eliminated medicationsserum creatinineserum cystatin c

Identifiers

PMID39601345
PMCPMC11693467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.