Evidence map›Paper›PMID 39601267›Full record

ArticleThe Journal of infectious diseases2025

Case-Control Study of Cervicovaginal β/γ-Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer.

Howard D Strickler, Mykhaylo Usyk, Isam-Eldin Eltoum, Natalie Bachman, Nancy A Hessol, Lisa Flowers, Lisa Rahangdale, Jessica M Atrio, Catalina Ramirez, Howard Minkoff and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Howard D StricklerDept of Epidemiology & Population Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
Mykhaylo UsykDept of Pediatrics, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
Isam-Eldin EltoumDept of Pathology, University of Alabama, Birmingham, Alabama, USA.
Natalie BachmanDept of Pediatrics, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
Nancy A HessolDept of Clinical Pharmacy, University of California, San Francisco, California, USA.
Lisa FlowersDept Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Lisa RahangdaleDept of Obstetrics & Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jessica M AtrioDept of Obstetrics and Gynecology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0002-3505-643X
Catalina RamirezDept of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-0872-0307
Howard MinkoffMaimonides Medical Center, Department of Obstetrics & Gynecology, Brooklyn, New York, USA.
Adaora A AdimoraDepartment of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Igho OfotokunDept of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-2735-1903
Marla J KellerDept of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0003-0417-4000
Margaret FischlDepartment of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Sadeep ShresthaDept of Pathology, University of Alabama, Birmingham, Alabama, USA.ORCID 0000-0002-7002-357X
Rodney WrightDept of Obstetrics and Gynecology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0001-7922-3503
Gypsyamber D'SouzaJohns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland, USA.
Lorraine Sanchez-KeelandUniversity of Southern California, Department of Obstetrics & Gynecology, Los Angeles, California, USA.
Xianhong XieDept of Epidemiology & Population Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
Xiaonan XueDept of Epidemiology & Population Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
Kathryn AnastosDept of Epidemiology & Population Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
L Stewart MassadWashington University School of Medicine, Department of Obstetrics & Gynecology, St Louis, Missouri, USA.ORCID 0000-0001-8486-9464
Joel M PalefskyDept of Medicine, University of California, San Francisco, California, USA.
Robert D BurkDept of Epidemiology & Population Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0002-8376-8458

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
MWCCS: Brooklyn Clinical Research SiteU01HL146202 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI TRACEY ELIZABETH WILSON, Jessica Eve Yager · 2019 to 2026
$23.6M
Atlanta WIHS U01-AI-035004Bronx WIHS U01-AI-031834Brooklyn WIHS U01-AI-034993Chicago WIHS U01-AI-034994Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentMontefiore-Einstein Comprehensive Cancer Center R01-CA230331National Institute of Allergy and Infectious Diseases P30-AI-050410National Institute on Mental HealthNCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NCATS NIH HHS UM1 TR004400NCI NIH HHS R01 CA230331NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146204NIAAA NIH HHSNIAID NIH HHS P30 AI050410NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NICHD NIH HHS U01 HD032632NIDA NIH HHSNIDCD NIH HHSNIDCR NIH HHSNIH Office of Research on Women's Health; UL1-TR000004Southern California WIHSWIHS Data Management and Analysis Center U01-HD-032632WIHS Northern California U01-AI-042590
6 · The paper itself

Abstract

We studied cervicovaginal β/γ-human papillomavirus (HPV) and their relationship to cervical precancer in women with human immunodeficiency virus; having previously reported strong positive associations of β/γ-HPV with incident head and neck cancer in the general population. Case patients (n = 124) had cervical intraepithelial neoplasia (CIN) 3 or 2. Controls (n = 247) were individually matched 2:1 to case patients. Unexpectedly, multivariate analyses found strong inverse associations between β/γ-HPV and CIN-2/3 (odds ratio, 0.19 [95% confidence interval, .04-.86]; P = .03; Ptrend < .01]). This is, to our knowledge, the first study of β/γ-HPV and cervical precancer. If confirmed, a strong inverse (protective) association would be of potential clinical and biologic relevance.

Indexed as

HIV InfectionsPapillomaviridaePapillomavirus InfectionsPrecancerous ConditionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAdultCase-Control StudiesCervix UteriFemaleHumansIncidenceMiddle Agedcervical precancerCIN-3human papillomavirus (HPV)women with HIV (WWH)β/γ-HPV

Identifiers

PMID39601267
PMCPMC11911781

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.