Evidence map›Paper›PMID 39601105›Full record

ArticleThe Laryngoscope2025

Serum S100A8/A9 Correlates to Surgery-Free Interval in Idiopathic Subglottic Stenosis.

Laura M Mafla, Raymond J So, Ibrahim Abd-Elazem, Samuel L Collins, Yee Chan-Li, Gabriela Lilly, Ioan A Lina, Alexander H Gelbard, Alexander T Hillel, Kevin M Motz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura M MaflaDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0002-9319-5761
Raymond J SoDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0003-1004-7606
Ibrahim Abd-ElazemDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
Samuel L CollinsDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
Yee Chan-LiDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0002-5357-8776
Gabriela LillyDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
Ioan A LinaDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0002-8619-7312
Alexander H GelbardDepartment of Otolaryngology Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.ORCID 0000-0003-0078-1305
Alexander T HillelDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0001-8471-5449
Kevin M MotzDepartment of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0002-9255-7265

Funding

Targeting mTOR regulation of T-lymphocytes and fibroblasts in Laryngotracheal StenosisR01DC018567 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLEL, ALEXANDER · 2020 to 2024
$3.8M
Molecular Interrogation of the Host-Pathogen Interface in Idiopathic Subglottic StensosisR01HL146401 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GELBARD, ALEXANDER · 2019 to 2023
$1.9M
E-cadherin deficient epithelium drives airway fibrosis in idiopathic subglottic stenosisR01HL174875 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Alexander Hillel · 2025 to 2026
$1.5M
Targeting pathologic macrophage activation through inhibition of MyD88 to attenuate laryngotracheal stenosisK23DC020988 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Kevin Motz · 2023 to 2026
$860k
Role of E-cadherin in epithelial barrier dysfunction and fibrosis in idiopathic subglottic stenosisR56DC020736 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLEL, ALEXANDER · 2023 to 2023
$154k
NHLBI NIH HHS R01 HL146401NHLBI NIH HHS R01HL146401-05NHLBI NIH HHS R01 HL174875NIDCD NIH HHS K23 DC020988NIDCD NIH HHS K23DC020988-02NIDCD NIH HHS R01 DC018567NIDCD NIH HHS R01DC018567-04NIDCD NIH HHS R56 DC020736NIDCD NIH HHS R56DC020736-07
6 · The paper itself

Abstract

objectiveIdiopathic subglottic stenosis (iSGS) is a progressive fibrotic condition of the subglottis that presents in women of northern European descent. Endoscopic dilation is a common surgical approach to management of iSGS. The surgery-free interval, or the time between endoscopic dilation procedures is considered an indicator of disease severity. Variations in surgery-free intervals among iSGS patients underscore the necessity for prognostic biomarkers. The objective of this study was to explore serum levels of the damage-associated molecular pattern S100A8/A9 as a prognostic biomarker in iSGS.

methodsSerum from 20 iSGS patients and eight healthy controls was collected and S100A8/A9 levels were quantified using an ELISA. Patient data, including demographics and surgery-free intervals, were obtained from medical records. Serum S100A8/A9 levels were compared to surgery-free intervals. S100A8/A9 was also assessed using gene expression and immunofluorescence in iSGS specimens.

resultsS100A8/A9 was significantly elevated (p = 0.0413) in the serum of iSGS patients compared to controls (312.75 vs. 181.49 ng/mL). Linear regression analysis revealed a correlation (p = 0.009) between S100A8/A9 levels and endoscopic surgery-free interval. S100A8/A9 was significantly elevated (p = 0.0011) in patients with surgery-free intervals less than 1 year (455.2 ± 60.45 ng/mL; n = 8) compared to patients with intervals over 1 year (292.5.93 ± 162.4; n = 6).

conclusionS100A8/A9 is increased in the serum and tissue of patients with iSGS. In this cohort of iSGS patients, serum S100A8/A9 was associated with surgery-free intervals, potentially representing a prognostic biomarker. Further research within a larger cohort is needed to confirm these findings. LEVEL OF EVIDENCE: 3 Laryngoscope, 135:1724-1731, 2025.

Indexed as

Calgranulin ACalgranulin BLaryngostenosisAdultAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedPrognosisBiomarkersCalgranulin ACalgranulin BS100A8 protein, humanS100A9 protein, humanidiopathic subglottic stenosislaryngotracheal stenosisS100A8/A9surgery‐free interval

Identifiers

PMID39601105
PMCPMC12802382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.