ArticleJournal of experimental pharmacology2024
Antidepressant-Like Effects of
Article in Journal of experimental pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Background: Depression continues to be a serious mental health problem among communities in Uganda, with limited access to mental healthcare services. Communities often use medicinal plants, such as Objective: Study assessed antidepressant-like effects of stem-leaf aqueous and total crude extracts of Methods: An experimental laboratory study was conducted on 36 Wistar albino rats (18 males, 18 females). Group I received normal saline, Group II received 10 mg/kg bwt escitalopram, Group III received 200 mg/kg bwt, Group IV received 1000 mg/kg bwt aqueous extract and same doses of total crude extract were used for Group V and Group VI, respectively, using intragastric tube. Depression-like behavior in rats was induced by several manipulations of CUS for 1-5 weeks. Sucrose preference test (SPT) was used to confirm depressive-like behaviors. Antidepressant-like effects were determined by FST. Durations of immobility, swimming, and struggling were recorded. Data were analyzed using STATA version 13. Results: In the chronic mild stress group, 19.2% preferred sucrose compared to 66.9% in the unstressed group (p<0.05). Conclusion: Aqueous extract of
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