Evidence map›Paper›PMID 39600725›Full record

ArticleEnvironmental science & technology letters2024

Serum Dioxin Levels in a Subset of Participants of the East Palestine, Ohio Train Derailment Health Tracking Study.

Erin N Haynes, Brenda Eskenazi, Timothy J Hilbert, Candace Brancato, Nina Holland, Christine Kim, Antonia M Calafat, Richard Jones, Mark Davis, Linda S Birnbaum and 1 more

Abstract read
In one paragraph

Article in Environmental science & technology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erin N HaynesUniversity of Kentucky, College of Public Health, Lexington, Kentucky 40536, United States.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California 94720, United States.
Timothy J HilbertUniversity of Cincinnati College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, Ohio 45267, United States.
Candace BrancatoUniversity of Kentucky, College of Public Health, Lexington, Kentucky 40536, United States.
Nina HollandCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California 94720, United States.
Christine KimUniversity of Kentucky, College of Public Health, Lexington, Kentucky 40536, United States.ORCID 0000-0001-5027-7591
Antonia M CalafatCenters for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, MS S103-2 Atlanta, Georgia, United States.
Richard JonesCenters for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, MS S103-2 Atlanta, Georgia, United States.
Mark DavisCenters for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, MS S103-2 Atlanta, Georgia, United States.
Linda S BirnbaumNicholas School of the Environment, Duke University, Durham, North Carolina 27710, United States.ORCID 0000-0001-5429-5658
Andreas SjodinCenters for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, MS S103-2 Atlanta, Georgia, United States.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Pilot Project ProgramP30ES026529 · NIEHS · UNIVERSITY OF KENTUCKY · PI Jason Unrine · 2017 to 2026
$15.4M
Retention, Maintenance and Enhancement of the Communities Actively Researching Exposure Study (CARES)R24ES030904 · NIEHS · UNIVERSITY OF KENTUCKY · PI HAYNES, ERIN N · 2020 to 2024
$1.8M
R21-UKY East Palestine Train Derailment Health Tracking StudyR21ES036036 · NIEHS · UNIVERSITY OF KENTUCKY · PI HAYNES, ERIN N · 2024 to 2025
$419k
NCATS NIH HHS UL1 TR001998NIEHS NIH HHS P30 ES026529NIEHS NIH HHS R21 ES036036NIEHS NIH HHS R24 ES030904
6 · The paper itself

Abstract

A February 3, 2023 train derailment and subsequent burn released hazardous chemicals into East Palestine, Ohio. One potential exposure was polychlorinated dibenzo-p-dioxins, dibenzofurans, and coplanar polychlorinated biphenyls (cPCBs), collectively referred to as dioxins. Many studies have linked dioxins to numerous health effects. A pilot study was conducted July 17-18, 2023 to assess residents' serum dioxin levels. Eighteen persons who were White, nonsmokers with a mean age of 55, and 56% female, provided serum for analysis. Measurement of 20 dioxins, furans, and cPCBs congeners was conducted using gas chromatography, isotope dilution, and high-resolution mass spectrometry. A toxic equivalency (TEQ) value for each participant was calculated by multiplying the reported concentration of each congener by its toxic equivalency factor and summing the results. TEQs were compared to 2011-2012 National Health and Nutrition Examination Survey (NHANES) data by race/ethnicity, sex, and age group. All participants had serum TEQ values either below or within the range of NHANES values. Mean TEQ values were lower in younger age groups; we observed no sex-specific differences. These pilot data demonstrate that although dioxins may have formed during the derailment, exposures to participants did not increase their TEQ values compared with 2011-2012 NHANES.

Indexed as

community-engaged researchdisaster response researchexposurereport-backrural

Identifiers

PMID39600725
PMCPMC11594446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.