Article in Neurology. Clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
5 authors.
Markus KarlanderInstitute of Neuroscience and Physiology (MK, SH, JL, AS, JZ), Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg University; Clinic of Neurology (MK, AS), Rehabilitation and Specialized Care at Home, Södra Älvsborg Hospital; Department of Research, Education and Innovation (MK, AS), Region Västra Götaland, Södra Älvsborg Hospital, Borås; Department of Neurology (SH, JZ), Sahlgrenska University Hospital; Wallenberg Center of Molecular and Translational Medicine (SH, JZ), Gothenburg University; and Department of Neurosurgery (JL), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-4262-3049
Samuel HåkanssonInstitute of Neuroscience and Physiology (MK, SH, JL, AS, JZ), Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg University; Clinic of Neurology (MK, AS), Rehabilitation and Specialized Care at Home, Södra Älvsborg Hospital; Department of Research, Education and Innovation (MK, AS), Region Västra Götaland, Södra Älvsborg Hospital, Borås; Department of Neurology (SH, JZ), Sahlgrenska University Hospital; Wallenberg Center of Molecular and Translational Medicine (SH, JZ), Gothenburg University; and Department of Neurosurgery (JL), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-8681-0113
Johan LjungqvistInstitute of Neuroscience and Physiology (MK, SH, JL, AS, JZ), Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg University; Clinic of Neurology (MK, AS), Rehabilitation and Specialized Care at Home, Södra Älvsborg Hospital; Department of Research, Education and Innovation (MK, AS), Region Västra Götaland, Södra Älvsborg Hospital, Borås; Department of Neurology (SH, JZ), Sahlgrenska University Hospital; Wallenberg Center of Molecular and Translational Medicine (SH, JZ), Gothenburg University; and Department of Neurosurgery (JL), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID https://orcid.org/0009-0000-9125-0985
Ann SörboInstitute of Neuroscience and Physiology (MK, SH, JL, AS, JZ), Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg University; Clinic of Neurology (MK, AS), Rehabilitation and Specialized Care at Home, Södra Älvsborg Hospital; Department of Research, Education and Innovation (MK, AS), Region Västra Götaland, Södra Älvsborg Hospital, Borås; Department of Neurology (SH, JZ), Sahlgrenska University Hospital; Wallenberg Center of Molecular and Translational Medicine (SH, JZ), Gothenburg University; and Department of Neurosurgery (JL), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-6744-6942
Johan ZelanoInstitute of Neuroscience and Physiology (MK, SH, JL, AS, JZ), Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg University; Clinic of Neurology (MK, AS), Rehabilitation and Specialized Care at Home, Södra Älvsborg Hospital; Department of Research, Education and Innovation (MK, AS), Region Västra Götaland, Södra Älvsborg Hospital, Borås; Department of Neurology (SH, JZ), Sahlgrenska University Hospital; Wallenberg Center of Molecular and Translational Medicine (SH, JZ), Gothenburg University; and Department of Neurosurgery (JL), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-9445-4545
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Background and Objectives: Traumatic brain injury (TBI) is a common cause of epilepsy, and the risk increases with injury severity. Whether a first posttraumatic seizure (PTS) represents epilepsy is a common clinical problem, but often unknown. Prognostication is important for providing correct patient information and consideration of antiseizure medication. Our objective was to understand how trauma severity and latency from the injury affect the risk of epilepsy after a first PTS. Methods: The register-based cohort study including all individuals hospitalized following a TBI in Sweden 2000-2010, in addition to 3 age-matched and sex-matched controls per case. We analyzed the 10-year probability of epilepsy following a first seizure using the Kaplan-Meier estimator. Results: The risk of an epilepsy diagnosis was 41.1% (95% CI 38.6-43.7) following a PTS, higher than the risk of 33.4% (95% CI 30.3-36.5) in those without prior TBI. The risk increased with injury severity, with the highest risk following focal cerebral injuries, 62.3% (95% CI 53.7-70.9). Mild injuries and skull fractures showed a similar risk to the group without previous TBI. In addition, the risk was higher if the seizure occurred <2 years following the trauma. Discussion: Severity of the injury and latency are major modulators of epilepsy risk following a first PTS. The risk was high in the most severe types of TBI, but a substantial proportion did not develop epilepsy, highlighting the need for further research on prognostication and biomarkers, as well as caution in diagnosing epilepsy based on a first PTS.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Risk of Epilepsy Following a First Posttraumatic Seizure: A Register-Based Study. · full record | OpenQuestion