ArticleNeurophotonics2024
Mid-infrared photoacoustic brain imaging enabled by cascaded gas-filled hollow-core fiber lasers.
Article in Neurophotonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Multi-spectral optoacoustic microscopy driven by gas-filled hollow-core fiber laser pulses.Biomedical optics express · 2025Article
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9 authors.
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Abstract
Significance: Extending the photoacoustic microscopy (PAM) into the mid-infrared (MIR) molecular fingerprint region constitutes a promising route toward label-free imaging of biological molecular structures. Realizing this objective requires a high-energy nanosecond MIR laser source. However, existing MIR laser technologies are limited to either low pulse energy or free-space structure that is sensitive to environmental conditions. Fiber lasers are promising technologies for PAM for their potential to offer both high pulse energy and robust performance, which however have not yet been used for PAM because it is still at the infant research stage. Aim: We aim to employ the emerging gas-filled anti-resonant hollow-core fiber (ARHCF) laser technology for MIR-PAM for the purpose of imaging myelin-rich regions in a mouse brain. Approach: This laser source is developed with a high-pulse-energy nanosecond laser at Results: The developed fiber Raman laser was used for the first time for MIR-PAM of mouse brain regions containing structures rich in myelin. The high peak power of Conclusions: We pioneered the potential use of high-energy and nanosecond gas-filled ARHCF laser source to MIR-PAM, with a first attempt to report this kind of fiber laser source for PAM of lipid-rich myelin regions in a mouse brain. We also open up possibilities for expanding into a versatile multiwavelength laser source covering multiple biomarkers and being employed to image other materials such as plastics.
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