ArticleFrontiers in genetics2024
Genetic screening of α-thalassemia fusion gene using routine flow-through hybridization.
Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- High prevalence of Hb Q-Thailand not in cis with the -αFrontiers in genetics · 2026Article
- Clinical application study of a novel fully automatic erythrocyte osmotic fragility analysis system.Biochemistry and biophysics reports · 2025Article
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6 authors.
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Abstract
Objective: The fusion gene is a rare form of α-thalassemia. Patients carrying the fusion gene could be misdiagnosed as normal or -α Methods: Samples were collected at our hospital from January 2019 to January 2024. Common thalassemia mutations in the Chinese population were conducted by flow-through hybridization. Samples showing faint coloration at the -α Results: Of the 32,083 samples, 25 samples (0.08%) were detected as suspected of having -α Conclusion: The fusion gene was present in 0.08% of the population in the Guangzhou region of Guangdong province, southern China. Conventional genetic methods tend to misdiagnose the fusion gene but can be effectively screened with flow-through hybridization.
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