Evidence map›Paper›PMID 39600312›Full record

ArticleFrontiers in chemistry2024

Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents.

Lamya H Al-Wahaibi, Mohamed A Mahmoud, Hayat Ali Alzahrani, Hesham A Abou-Zied, Alshaimaa Abdelmoez, Bahaa G M Youssif, Stefan Bräse, Safwat M Rabea

Abstract read
In one paragraph

Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Mohamed A MahmoudPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Hayat Ali AlzahraniApplied Medical Science College, Medical Laboratory Technology Department, Northern Border University, Arar, Saudi Arabia.
Hesham A Abou-ZiedMedicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Alshaimaa AbdelmoezPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Bahaa G M YoussifPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Stefan BräseInstitute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology, Karlsruhe, Germany.
Safwat M RabeaMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bacteria have acquired resistance to almost all antibiotics currently in use due to their extensive, broad, and improper utilization over a prolonged period. DNA gyrase and DHFR exhibit significant promise as targets for antibacterial therapeutics. Methods: We have developed a series of disalicylic acid methylene/Schiff bases hybrids ( Results and discussion: The findings showed that

Indexed as

bacterial resistancebactericidalbiofilmDNAisatinsalicylic acid

Identifiers

PMID39600312
PMCPMC11590026

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.