Evidence map›Paper›PMID 39600306›Full record

ArticleiScience2024

The role of osteocrin in memory formation during early learning, as revealed by visual imprinting in chicks.

Tomoharu Nakamori, Izumi Komatsuzawa, Umi Iwata, Ami Makita, Go Kagiya, Kazuko Fujitani, Tetsuya Kitaguchi, Takashi Tsuboi, Hiroko Ohki-Hamazaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tomoharu NakamoriCollege of Liberal Arts and Sciences, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
Izumi KomatsuzawaCollege of Liberal Arts and Sciences, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
Umi IwataCollege of Liberal Arts and Sciences, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
Ami MakitaCollege of Liberal Arts and Sciences, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
Go KagiyaSchool of Allied Health Sciences, and Regenerative Medicine and Cell Design Research Facility, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan.
Kazuko FujitaniGene Analysis Center, School of Medicine, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan.
Tetsuya KitaguchiLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Takashi TsuboiDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Hiroko Ohki-HamazakiCollege of Liberal Arts and Sciences, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteocrin (OSTN) is structurally associated with natriuretic peptides. Its expression in the brain, which has only been recognized in anthropoid primates, is induced by sensory stimuli and regulates the activity-dependent dendritic growth of neurons. However, details on the signaling mechanisms of OSTN and its function in plastic changes during learning and memory have yet to be elucidated. We found that OSTN was expressed in the cortical region of the chicken brain. The injection of chicken OSTN (chOSTN) after imprinting training prolonged the memory retention for the imprinting stimulus. Conversely, a reduction in the OSTN receptor chNPR3 inhibited memory retention. The memory retention was positively correlated with a high level of chOSTN and fewer neurites in the cortical region. In conclusion, OSTN-NPR3 signaling promoted memory consolidation and/or retention by regulating neurite branching during childhood.

Indexed as

Cognitive neuroscienceNeuroscience

Identifiers

PMID39600306
PMCPMC11591550

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.