ArticleJournal of cosmetic dermatology2025
Evaluation of the In Vivo Skin Penetration of TXVector by Confocal Raman Spectroscopy.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Magnetic resonance and X-ray contrast agents in the optical clearing of dermis - insights fromBiomedical optics express · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranexamic acid (TXA) is a promising active to treat hyperpigmentation disorders, such as melasma and acne scars. However, TXA is highly hydrophilic and its penetration into the skin is poor and formulation dependent.
aimsIn this study, our aim was to evaluate the in vivo skin penetration of an ester-modified TXA, TXVector, directly on the skin of volunteers.
methodsFor the analysis of in vivo skin penetration of TXVector, we used in vivo confocal Raman spectroscopy (CRS). The use of CRS on live skin allows us to study directly how a compound affects skin composition at different depths and how this compound penetrates into the skin in real time.
resultsOur results showed that the TXA absorption into the skin via TXVector was 2.1-fold and 3.8-fold higher compared to free TXA 3% and TXA 1% formulations, respectively. Most importantly, upon application of TXVector, the TXA penetration flux into the skin was 107% and 280% higher than that of the free TXA 3% and TXA 1% formulations, respectively.
conclusionsIn summary, this study shows that the esterification-based TXVector formulation enhances the penetration flux of TXA and increases its bioavailability in the skin.
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Registered trials
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