ArticleRapid communications in mass spectrometry : RCM2025
Same, but different: Variations in fragment ions among stereoisomers of a 17α-methyl steroid in gas chromatography/electron ionization mass spectrometry.
Article in Rapid communications in mass spectrometry : RCM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026Review
- Evaluation of Different Detection and Identification Methods of Intact Tetrahydro-Methyltestosterone Sulfate Metabolites in Doping Control.Drug testing and analysis · 2026Article
- Spatial Mapping of Stereoisomeric and Isobaric Alkaloids inAnalytical chemistry · 2025Article
- Overcoming the Challenge of Confident Identification Among Two Related Groups of 17-Methyl Steroids by GC-MS.Journal of separation science · 2025Article
- Characterization and metabolic profiling of oxymetholone and methasterone metabolites studied with human liver S9 model using GC-Orbitrap-HRMS for anti-doping purposes.Analytical and bioanalytical chemistry · 2025Article
- Same, but different: Variations in fragment ions among stereoisomers of a 17α-methyl steroid in gas chromatography/electron ionization mass spectrometry.Rapid communications in mass spectrometry : RCM · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
rationaleGas chromatography/electron ionization mass spectrometry (GC/EI-MS) is a well-established tool for the identification of unknown compounds such as new metabolites of xenobiotics. But it reaches the limits of confident structural assignment if it comes to stereoisomers. This work helps to overcome this difficulty by getting a deeper comprehension of composition of so far unspecific and also characteristic fragment ions in general and comparison among stereoisomers.
methodsUnit mass resolution mass spectra of various isotopologues of four 17α-methyl steroid diastereomers obtained by selectively introducing [
resultsThe formation of fragment ions from TMS-derivatives after cleavage of methyl or TMS groups ([M-CH
conclusionsStereoisomers showed differing fragmentation behaviors based on their configuration. These observations further illustrate that variations among stereoisomers in EI-MS fragmentation is no random underlying process but instead a pattern which needs to be understood in its complexity. This easily accessible technical approach can be applied on different molecule structures to further investigate the field of isomeric assignment in GC/EI-MS.
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Registered trials
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