Evidence map›Paper›PMID 39600137›Full record

ReviewDeutsches Arzteblatt international2024

The Epidemiology and Diagnosis of Measles—Special Aspects Relating to Low Incidence.

Dorothea Matysiak-Klose, Annette Mankertz, Heidemarie Holzmann

Abstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Booster Vaccinations Are Required.Deutsches Arzteblatt international · 2025
    Article
  4. In Reply.Deutsches Arzteblatt international · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dorothea Matysiak-KloseDepartment of Infectious Disease Epidemiology, Immunization Unit, Robert Koch Institute, Berlin, Germany; Department of Infectious Diseases, Measles, Mumps, Rubella, and Viruses Affecting Immunocompormised Patients, Robert Koch Institute, Berlin, Germany; Scientific Commitees, National Verification Committee for Measles and Rubella elimination in Germany, Berlin, Germany.
Annette Mankertz
Heidemarie Holzmann

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeasles is a highly contagious viral disease (contagion index near 100%) with a complication rate of up to 30%. The worldwide incidence for 2022 was calculated as 29 cases per million people. Measles can be eliminated if 95% of the population is either vaccinated or immune and measures are taken to limit its spread as soon as an initial suspected case is encountered. However, the worldwide immunization rate has fallen since 2020 (from 86% in 2019 to 81% in 2021).

methodsTo assess the epidemiological situation and describe the state of scientific knowledge regarding laboratory tests for measles, we analyzed recent epidemiological data from the Robert-Koch Institute (RKI) and reviewed pertinent publications retrieved by a selective literature search.

resultsRepeated importations of measles virus have led to a new rise in case numbers in Germany since last year. 79 cases of measles were reported to the RKI in 2023, and 475 in the first eight months of 2024. The latter figure corresponds to the pre-pandemic level. There are still immunization gaps in the population: for instance, by the age of 24 months, 93.7% of children have received their first immunization, and only 80.5% have received the second. Every suspected case must be confirmed by laboratory testing so that targeted measures can be initiated. Serology is no longer considered sufficiently reliable; a reliable diagnosis now requires a poly merase chain reaction (PCR) test. The specimen can be a throat swab or a urine sample. PCR also enables the differentiation of measles virus variants and the tracing of transmission chains.

conclusionReliable laboratory testing makes it possible to detect measles cases rapidly, initiate measures to slow the spread of the disease, trace infection chains, and assess the risk exposure for measles in Germany.

Indexed as

Disease OutbreaksMeaslesAdolescentChildChild, PreschoolFemaleGermanyHumansIncidenceInfantMaleMeasles VaccineMeasles Vaccine

Identifiers

PMID39600137
PMCPMC12104989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.