Evidence map›Paper›PMID 39600047›Full record

ArticleChemistryOpen2025

Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and in Vitro Anticancer Studies.

Padyala Panduranga, Parameshwar Makam, Naresh Kumar Katari, Rambabu Gundla, Sreekantha Babu Jonnalagadda, Bharat Kumar Tripuramallu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Padyala PandurangaDepartment of Chemistry, VFSTR (Deemed to be University), Vadlamudi, Guntur, Andhra Pradesh, 522213, India.
Parameshwar MakamDivision of Research and Innovation, Department of Chemistry, Uttaranchal University,Arcadia Grant, P.O. Chandanwari, Premnagar, Dehradun Uttarakhand, 248007, India.
Naresh Kumar KatariSchool of Chemistry & Physics, College of Agriculture, Engineering & Science, Westville Campus, University of KwaZulu-Natal, P Bag X 54001, Durban, 4000, South Africa.ORCID 0000-0002-5737-8528
Rambabu GundlaDepartment of Chemistry, GITAM School of Science, GITAM Deemed to be University, Hyderabad, Telangana, 502329, India.
Sreekantha Babu JonnalagaddaSchool of Chemistry & Physics, College of Agriculture, Engineering & Science, Westville Campus, University of KwaZulu-Natal, P Bag X 54001, Durban, 4000, South Africa.
Bharat Kumar TripuramalluDepartment of Chemistry, VFSTR (Deemed to be University), Vadlamudi, Guntur, Andhra Pradesh, 522213, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular hybrids of diversely functionalized quinoline and sulfonamide have been designed. Multistep synthetic strategies have been used for the synthesis. The anti-cancer properties have been evaluated against various cancer cell lines including HCT116, A549, U2OS, CCRF-CEM, Jurkat, MOLT-4, RAMOS, and K562. Non-cancer cell lines MRC-5 and BJ were also included for comparison. When examining the effects on A549, HCT116, and U2OS cells, all tested compounds exhibited limited potency with IC

Indexed as

Antineoplastic AgentsDrug DesignQuinolinesSulfonamidesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsquinolineQuinolinesSulfonamidesMolecular hybridsQuinolineSulfonamideSynthesis and in vitro anticancer study

Identifiers

PMID39600047
PMCPMC12128149

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.