Evidence map›Paper›PMID 39599963›Full record

ArticleChemistryOpen2025

Toward Polymeric Room Temperature Acid Generators.

Joel W Roberts, Amie N Lanzendorf, Jazmin E Aguilar-Romero, Mara L Paterson, Catherine A Jalomo, Ephraim G Morado, Steven C Zimmerman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joel W RobertsDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID https://orcid.org/0009-0007-5916-3778
Amie N LanzendorfDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Jazmin E Aguilar-RomeroDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Mara L PatersonDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID https://orcid.org/0000-0003-1511-2251
Catherine A JalomoDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Ephraim G MoradoDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Steven C ZimmermanDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID https://orcid.org/0000-0002-5333-3437

Funding

Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Small Molecule Approaches to Targeting the DNA and RNA in Myotonic DystrophyR01AR069645 · NIAMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZIMMERMAN, STEVEN C. · 2017 to 2021
$2.2M
National Science Foundation NSF CHE-1709718NIAMS NIH HHS R01 AR069645NIGMS NIH HHS T32 GM070421NIH Chemistry- Biology Interface Training Grant NRSA 1-T-32-GM070421NIH HHS R01AR069645
6 · The paper itself

Abstract

Although a variety of acid-generating molecules have been developed, the formation of toxic byproducts and the need for light-activation or temperatures that may be incompatible with physiological conditions leave room for the optimization of biocompatible acid-generators. Herein, we report 4-hydroxybenzyl chloride derivatives that generate hydrochloric acid via hydrolysis at the benzylic position at room temperature in the absence of light. Utilizing the acetal protected 4-hydroxybenzyl chloride scaffold, we access a myriad of compounds that generate acid at different rates.

Indexed as

Acid amplificationAcid generatorCancerDrug deliveryExtra cellular pH

Identifiers

PMID39599963
PMCPMC11891450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.