Evidence map›Paper›PMID 39599916›Full record

ArticleViruses2024

Chimeric Virus-like Particles of Physalis Mottle Virus as Carriers of M2e Peptides of Influenza a Virus.

Elena A Blokhina, Eugenia S Mardanova, Anna A Zykova, Marina A Shuklina, Liudmila A Stepanova, Liudmila M Tsybalova, Nikolai V Ravin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elena A BlokhinaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-6038-3715
Eugenia S MardanovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0003-2148-7658
Anna A ZykovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0001-9577-4815
Marina A ShuklinaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0002-7550-5519
Liudmila A StepanovaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0002-8731-1834
Liudmila M TsybalovaSmorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376 St. Petersburg, Russia.ORCID 0000-0002-1193-5907
Nikolai V RavinInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-1456-1832

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2022-318
6 · The paper itself

Abstract

Plant viruses and virus-like particles (VLPs) are safe for mammals and can be used as a carrier/platform for the presentation of foreign antigens in vaccine development. The aim of this study was to use the coat protein (CP) of Physalis mottle virus (PhMV) as a carrier to display the extracellular domain of the transmembrane protein M2 of influenza A virus (M2e). M2e is a highly conserved antigen, but to induce an effective immune response it must be linked to an adjuvant or carrier VLP. Four tandem copies of M2e were either fused to the N-terminus of the full-length PhMV CP or replaced the 43 N-terminal amino acids of the PhMV CP. Only the first fusion protein was successfully expressed in

Indexed as

Antibodies, ViralInfluenza A virusInfluenza VaccinesOrthomyxoviridae InfectionsVaccines, Virus-Like ParticleViral Matrix ProteinsAnimalsCapsid ProteinsFemaleImmunizationImmunoglobulin GMiceMice, Inbred BALB CPeptidesRecombinant Fusion ProteinsTombusviridaeAntibodies, ViralCapsid ProteinsImmunoglobulin GInfluenza VaccinesM2 protein, Influenza A virusPeptidesRecombinant Fusion ProteinsVaccines, Virus-Like ParticleViral Matrix ProteinsViroporin Proteinsinfluenza A virusM2e peptidePhysalis mottle virusvaccinevirus-like particle

Identifiers

PMID39599916
PMCPMC11598990

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.