Evidence map›Paper›PMID 39599899›Full record

ArticleViruses2024

Respiratory Viral Infection Patterns in Hospitalised Children Before and After COVID-19 in Hong Kong.

Jason Chun Sang Pun, Kin Pong Tao, Stacy Lok Sze Yam, Kam Lun Hon, Paul Kay Sheung Chan, Albert Martin Li, Renee Wan Yi Chan

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Observational
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  7. Review
  8. Article
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  12. Review
  13. Changing Trends in Paediatric Acute Respiratory Infections:Sultan Qaboos University medical journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jason Chun Sang PunDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.ORCID 0000-0003-2650-922X
Kin Pong TaoDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.ORCID 0009-0003-7843-1740
Stacy Lok Sze YamDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.
Kam Lun HonDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.
Paul Kay Sheung ChanDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.ORCID 0000-0002-6360-4608
Albert Martin LiDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.
Renee Wan Yi ChanDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.ORCID 0000-0001-6485-0926

Funding

HMRF - Commissioned Programme for Influenza Research INF-CUHK-2
6 · The paper itself

Abstract

The study highlights the significant changes in respiratory virus epidemiology following the lifting of COVID-19 restrictions.

methodIn this single-centre retrospective study, the virological readouts of adenovirus (AdV), influenza virus A (IAV), influenza virus B (IBV), parainfluenza viruses (PIV) 1, 2, 3, 4, respiratory syncytial virus (RSV), and coupled enterovirus and rhinovirus (EV/RV) were extracted from the respiratory specimens of paediatric patients in Hong Kong from January 2015 to February 2024. The subjects were stratified into five age groups.

resultsThe study included 18,737 and 6001 respiratory specimens in the pre-COVID-19 and post-COVID-19 mask mandate period, respectively. The mean age of hospitalised patients increased from 3.49 y ± 0.03 y to 4.37 y ± 0.05 y after the COVID-19 lockdown. The rates of single-virus infection and co-infection were significantly higher in the post-COVID-19 mask mandate period. The odds ratio for AdV for all age groups (OR: 4.53, 4.03, 2.32, 2.46, 1.31) and RSV in older children from 3 years old and above (OR: 1.95, 3.38,

conclusionsOur findings suggest that public health measures to contain COVID-19 may have unintended consequences on children's natural exposure and immunity to other respiratory viruses, potentially increasing their morbidity in the post-pandemic era.

Indexed as

CoinfectionCOVID-19HospitalizationRespiratory Tract InfectionsSARS-CoV-2ChildChild, PreschoolFemaleHong KongHumansInfantMaleRetrospective StudiesVirus Diseasesage-specific responsesco-infection of respiratory virusespaediatric respiratory virus epidemiologypost-COVID-19

Identifiers

PMID39599899
PMCPMC11599058

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.