Evidence map›Paper›PMID 39599853›Full record

ReviewViruses2024

Acute Hepatitis C: Current Status and Future Perspectives.

Massimo Fasano, Francesco Ieva, Marianna Ciarallo, Bruno Caccianotti, Teresa Antonia Santantonio

Abstract readReview
In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Epigenetic Mechanisms Involved in Hcv Infection and Human HCC.International journal of molecular sciences · 2025
    Review
  4. Review
  5. [Recent Advances in the Treatment of Chronic Hepatitis C].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Massimo FasanoInfectious Diseases Unit, PO Della Murgia "F. Perinei", 70022 Altamura, Italy.
Francesco IevaDepartment of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.
Marianna CiaralloDepartment of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.
Bruno CaccianottiDepartment of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.
Teresa Antonia SantantonioDepartment of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-4342-6904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hepatitis C virus (HCV) infection continues to represent a significant public health threat and is a leading cause of liver cirrhosis, liver cancer, and liver-related mortality. The World Health Organization (WHO) has set a goal for 2030: to eliminate HCV infection as a public health threat by reducing new HCV infections by 90% and mortality by 65%. The early phase of HCV infection represents a pivotal point in the evolution of hepatitis C. Despite a favourable course in the majority of patients, approximately 50-70% of individuals with recently acquired hepatitis C will develop a chronic infection, defined as the persistence of viremia for a period exceeding six months. The diagnosis and treatment of a recent HCV infection should facilitate engagement in multidisciplinary care, prevent the development and complications of chronic liver disease, and reduce ongoing transmission in key populations. Therefore, early treatment in the early phase of infection compared with deferring treatment until the chronic infection remains a valid approach in the era of direct antiviral agents (DAAs). This approach is supported by a cost-effectiveness analysis. The aim of this review is to synthesise the existing knowledge on the early phase of hepatitis C virus infection, with a particular focus on the current risk factors, natural history, therapeutic management, and future perspectives.

Indexed as

Antiviral AgentsHepacivirusHepatitis CAcute DiseaseHumansRisk FactorsAntiviral AgentsDAA therapyearly phase of infectionhepatitis C virusmodes of transmissionnatural history

Identifiers

PMID39599853
PMCPMC11599108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.