Evidence map›Paper›PMID 39599852›Full record

ReviewViruses2024

TRIM Proteins: Key Regulators of Immunity to Herpesvirus Infection.

Zuberwasim Sayyad, Dhiraj Acharya, Michaela U Gack

Abstract readReview
In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Inhibition of coronaviral exoribonuclease activity by TRIM-mediated SUMOylation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zuberwasim SayyadFlorida Research and Innovation Center, Cleveland Clinic, 9801 SW Discovery Way, Port St. Lucie, FL 34987, USA.ORCID 0000-0003-1799-7604
Dhiraj AcharyaFlorida Research and Innovation Center, Cleveland Clinic, 9801 SW Discovery Way, Port St. Lucie, FL 34987, USA.
Michaela U GackFlorida Research and Innovation Center, Cleveland Clinic, 9801 SW Discovery Way, Port St. Lucie, FL 34987, USA.

Funding

Defining the viral PTMome: Towards the development of novel antiviral approachesDP1AI169444 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI GACK, MICHAELA ULRIKE · 2021 to 2025
$5.6M
Regulation of Host Innate Immunity Against Viral InfectionR01AI087846 · NIAID · UNIVERSITY OF CHICAGO · PI GACK, MICHAELA ULRIKE · 2010 to 2020
$3.9M
Regulation of Host Innate Immunity Against Viral InfectionR37AI087846 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Michaela Ulrike Gack · 2021 to 2026
$2.8M
Novel Role for Host Immunostimulatory RNA in Antiviral Immune DefenseR01AI165502 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI GACK, MICHAELA ULRIKE · 2021 to 2025
$2.3M
The Role of TRIM23 in Autophagy Mediated Antiviral DefensesR01AI148534 · NIAID · UNIVERSITY OF CHICAGO · PI GACK, MICHAELA ULRIKE · 2020 to 2024
$2.3M
NIAID NIH HHS DP1 AI169444NIAID NIH HHS R01 AI087846NIAID NIH HHS R01 AI148534NIAID NIH HHS R01 AI165502NIAID NIH HHS R37 AI087846NIH HHS AI148534, AI165502, AI087846, and AI169444
6 · The paper itself

Abstract

Herpesviruses are ubiquitous DNA viruses that can establish latency and cause a range of mild to life-threatening diseases in humans. Upon infection, herpesviruses trigger the activation of several host antiviral defense programs that play critical roles in curbing virus replication and dissemination. Recent work from many groups has integrated our understanding of TRIM (

Indexed as

Herpesviridae InfectionsImmunity, InnateTripartite Motif ProteinsVirus ReplicationAnimalsApoptosisAutophagyHerpesviridaeHerpesvirus 1, HumanHost-Pathogen InteractionsHumansSignal TransductionToll-Like ReceptorsUbiquitin-Protein LigasesToll-Like ReceptorsTripartite Motif ProteinsUbiquitin-Protein LigasesapoptosisautophagycGASherpesvirusHSV-1innate immunityRIG-I-like receptorsSTINGToll-like receptorsTRIM proteins

Identifiers

PMID39599852
PMCPMC11599090

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.