Evidence map›Paper›PMID 39599849›Full record

ArticleViruses2024

Serum microRNA 143 and 223 Gene Expression Profiles as Potential Biomarkers in Individuals with Hepatitis and COVID-19.

Lucas Lima da Silva, Luciane Almeida Amado Leon, Otacílio da Cruz Moreira, Wagner Luis da Costa Nunes Pimentel Coelho, Vanessa Duarte da Costa, Claudia Alexandra Pontes Ivantes, Priscila Pollo-Flores, Lia Laura Lewis-Ximenez, Vanessa Salete de Paula, Livia Melo Villar

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lucas Lima da SilvaNational Reference Laboratory for Viral Hepatitis, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.ORCID 0000-0002-2562-1650
Luciane Almeida Amado LeonTechnological Development Laboratory, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.ORCID 0000-0002-7919-8915
Otacílio da Cruz MoreiraMolecular Virology and Parasitology Laboratory, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.ORCID 0000-0002-5340-8697
Wagner Luis da Costa Nunes Pimentel CoelhoTechnological Development Laboratory, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.
Vanessa Duarte da CostaNational Reference Laboratory for Viral Hepatitis, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.
Claudia Alexandra Pontes IvantesGastroenterology, Hepatology and Liver Transplantation Service, Nossa Senhora das Graças, Curitiba 80810-040, PR, Brazil.ORCID 0000-0001-5422-557X
Priscila Pollo-FloresDepartment of Clinical Medicine, Fluminense Federal University, Niterói 24220-000, RJ, Brazil.ORCID 0000-0001-5358-5426
Lia Laura Lewis-XimenezNational Reference Laboratory for Viral Hepatitis, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.
Vanessa Salete de PaulaMolecular Virology and Parasitology Laboratory, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.ORCID 0000-0002-6314-754X
Livia Melo VillarNational Reference Laboratory for Viral Hepatitis, Institute Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, RJ, Brazil.ORCID 0000-0001-7644-8969

Funding

CAPES 88887.506556/2020-00FAPERJ E-26/204.197/2021National Council for Scientific and Technological Development 315967/2021-8OSWALDO CRUZ FOUNDATION INOVA COVID 484015522386498
6 · The paper itself

Abstract

MicroRNAs (miRNAs) can act as biomarkers and descriptors of the association between infections and other diseases, such as hepatitis and COVID-19. This study aims to investigate the role of miRNA serum expression according to laboratory data concerning hepatitis and COVID-19. Seventy individuals recruited in Southern and Southeastern Brazil donated serum samples and were divided into four groups: (i) 20 negative subjects, (ii) 20 presenting hepatitis, (iii) 19 with COVID-19 and (iv) 11 with hepatitis and COVID-19. Three miRNAs (miR-122, miR-143 and miR-223) were evaluated using real-time PCR. Hematological and biochemical markers were also analyzed. MiR-143 and miR-223 were downregulated among the hepatitis/COVID-19 group (

Indexed as

BiomarkersCOVID-19MicroRNAsSARS-CoV-2AdultAgedAlanine TransaminaseAspartate AminotransferasesBrazilFemaleGene Expression ProfilingHepatitisHumansMaleMiddle AgedAlanine TransaminaseAspartate AminotransferasesBiomarkersMicroRNAsMIR223, humanMIRN143 microRNA, humanbiomarkerCOVID-19hepatitismicroRNA

Identifiers

PMID39599849
PMCPMC11598994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.