Evidence map›Paper›PMID 39599822›Full record

ArticleViruses2024

Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma.

Sasipa Tanyaratsrisakul, Yury A Bochkov, Vanessa White, Heejung Lee, Jessica Loeffler, Jamie Everman, Allison M Schiltz, Kristy L Freeman, Katharine L Hamlington, Elizabeth A Secor and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sasipa TanyaratsrisakulDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-2188-5990
Yury A BochkovDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.ORCID 0000-0003-2618-4496
Vanessa WhiteDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.ORCID 0009-0001-5500-4098
Heejung LeeDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Jessica LoefflerDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Jamie EvermanCenter for Genes, Environment and Health, National Jewish Health, Denver, CO 80206, USA.
Allison M SchiltzSection of Pediatric Pulmonary & Sleep Medicine, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO 80045, USA.
Kristy L FreemanSection of Pediatric Pulmonary & Sleep Medicine, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO 80045, USA.
Katharine L HamlingtonSection of Pediatric Pulmonary & Sleep Medicine, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-5221-2123
Elizabeth A SecorCenter for Genes, Environment and Health, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-6957-5561
Nathan D JacksonCenter for Genes, Environment and Health, National Jewish Health, Denver, CO 80206, USA.
Hong Wei ChuDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Andrew H LiuSection of Pediatric Pulmonary & Sleep Medicine, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO 80045, USA.
Julie G LedfordAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0001-7977-4575
Monica KraftDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Max A SeiboldCenter for Genes, Environment and Health, National Jewish Health, Denver, CO 80206, USA.
Dennis R VoelkerDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Mari NumataDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-6310-6801

Funding

Tollip inhibits IL-33 signaling during airway influenza virus infectionU19AI125357 · NIAID · UNIVERSITY OF ARIZONA · PI CARR, TARA F · 2016 to 2025
$14.7M
Transcriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2017 to 2021
$9.0M
Mechanisms of Enhanced Neutralizing Antibody Responses to Rhinovirus CR01AI148707 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BOCHKOV, YURY A · 2020 to 2024
$3.9M
Phospholipid-Protein Interactions Regulating Viral InfectionR01GM118819 · NIGMS · NATIONAL JEWISH HEALTH · PI NUMATA-NAKAMURA, MARI · 2017 to 2020
$1.3M
Determining the Role of Creatine Kinase in AsthmaR21AI178782 · NIAID · UNIVERSITY OF ARIZONA · PI LEDFORD, JULIE GUNNELLS · 2023 to 2024
$422k
Flight Attendant Medical Research Institute, Inc. CIA 160010National Emphysema Foundation N/ANHLBI NIH HHS HL132821NHLBI NIH HHS P01 HL132821NIAID NIH HHS 2U19 -Al 125357NIAID NIH HHS AI148707NIAID NIH HHS AI178782NIAID NIH HHS R01 AI148707NIAID NIH HHS R21 AI178782NIGMS NIH HHS 118819NIGMS NIH HHS R01 GM118819
6 · The paper itself

Abstract

Rhinovirus C (RV-C) infection can trigger asthma exacerbations in children and adults, and RV-C-induced wheezing illnesses in preschool children correlate with the development of childhood asthma. Surfactant protein A (SP-A) plays a critical role in regulating pulmonary innate immunity by binding to numerous respiratory pathogens. Mature SP-A consists of multiple isoforms that form the hetero-oligomers of SP-A1 and SP-A2, organized in 18-mers. In this report, we examined the efficacy of SP-A to antagonize RV-C infection using the wild-type (RV-C15) and reporter-expressing (RV-C15-GFP) viruses in differentiated nasal epithelial cells (NECs) from asthmatic and non-asthmatic children. We also determined the antiviral mechanism of action of SP-A on RV-C15 infection. The native SP-A was purified from alveolar proteinosis patients. The recombinant (r) SP-A1 and SP-A2 variants were expressed in FreeStyle™ 293-F cells. SP-A reduced the fluorescent focus-forming units (FFUs) after RV-C15-GFP infection of NECs by 99%. Both simultaneous and 4 h post-infection treatment with SP-A inhibited RV-C15 and RV-C15-GFP viral RNA load by 97%. In addition, the antiviral genes and chemokines (IFN-λ, IRF-7, MDA-5, and CXLC11) were not induced in the infected NECs due to the inhibition of RV-C propagation by SP-A. Furthermore, SP-A bound strongly to RV-C15 in a dose- and Ca

Indexed as

AsthmaEpithelial CellsPulmonary Surfactant-Associated Protein AChildChild, PreschoolEnterovirusHumansPicornaviridae InfectionsRhinovirusVirus AttachmentPulmonary Surfactant-Associated Protein ASFTPA1 protein, humanSFTPA2 protein, humanhuman rhinovirus Cinnate immunitypediatric asthmapulmonary surfactant protein A

Identifiers

PMID39599822
PMCPMC11598966

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.