Evidence map›Paper›PMID 39599792›Full record

ArticleViruses2024

The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis.

Carolyn Enochs, Gabriela Delevati Colpo, Lucy Couture, Lynae Baskin, Ana E Cahuiche, Eunyoung Angela Lee, Shahid Nimjee, Louise D McCullough

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. COVID-19: a vascular nightmare unfolding.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolyn EnochsDepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.ORCID 0009-0005-3917-2816
Gabriela Delevati ColpoDepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.
Lucy CoutureDepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.ORCID 0000-0002-1586-988X
Lynae BaskinDepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.ORCID 0009-0004-8263-3975
Ana E CahuicheDepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.
Eunyoung Angela LeeDepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.ORCID 0000-0002-9440-9119
Shahid NimjeeNeurosurgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.ORCID 0000-0002-0317-8731
Louise D McCulloughDepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.

Funding

Sex specific immune response to SARS-CoV-2 leads to chronic neurologic symptomsR01MH127856 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, FUDONG, MCCULLOUGH, LOUISE D. · 2021 to 2025
$3.7M
A Novel Thrombolytic Targeting Von Willebrand Factor (VWF) to Treat Ischemic StrokeR01NS123687 · NINDS · OHIO STATE UNIVERSITY · PI NIMJEE, SHAHID · 2021 to 2025
$2.5M
NIH HHS 1R01MH127856-01NIMH NIH HHS R01 MH127856NINDS NIH HHS R01 NS123687
6 · The paper itself

Abstract

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, 61 patients who experienced thrombotic events had the event after initial blood collection, so the predictive capacity of biomarkers in these patients was evaluated. Citrullinated histone H3 was the best predictive biomarker for thrombotic events in COVID-19 regardless of age, sex, and race; disease severity was also a significant predictor in most thrombotic event groups. These results may better inform treatment and prophylaxis of thrombotic events in COVID-19 and similar viral illnesses in the future to improve outcomes and reduce mortality.

Indexed as

BiomarkersCOVID-19Extracellular TrapsSARS-CoV-2ThrombosisAdultAgedBlood Coagulation DisordersFemaleHistonesHumansMaleMiddle AgedNeutrophilsvon Willebrand FactorBiomarkersHistonesvon Willebrand FactorcoagulationcoronavirusCOVID-19epidemiologyneutrophil extracellular trapthrombosisviral infection

Identifiers

PMID39599792
PMCPMC11598969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.