Evidence map›Paper›PMID 39599727›Full record

ArticleNutrients2024

Characterization of the Gut and Skin Microbiome over Time in Young Children with IgE-Mediated Food Allergy.

Michèle S Roth, Muriel d'Aujourd'hui, Axel Künstner, Misa Hirose, Michael Olbrich, Saleh Ibrahim, Karin Hartmann, Caroline Roduit, Hauke Busch, Felicitas Bellutti Enders

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michèle S RothDivision of Pediatric Allergy, University Children's Hospital Basel, 4031 Basel, Switzerland.ORCID 0000-0001-5753-1046
Muriel d'Aujourd'huiDivision of Pediatric Allergy, University Children's Hospital Basel, 4031 Basel, Switzerland.
Axel KünstnerInstitute for Experimental Dermatology, University of Lubeck, 23538 Lubeck, Germany.ORCID 0000-0003-0692-2105
Misa HiroseInstitute for Experimental Dermatology, University of Lubeck, 23538 Lubeck, Germany.ORCID 0000-0002-8909-4693
Michael OlbrichInstitute for Experimental Dermatology, University of Lubeck, 23538 Lubeck, Germany.ORCID 0000-0003-2789-3382
Saleh IbrahimInstitute for Experimental Dermatology, University of Lubeck, 23538 Lubeck, Germany.
Karin HartmannDivision of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.ORCID 0000-0002-4595-8226
Caroline RoduitChildren's Hospital of Eastern Switzerland, 9000 St. Gallen, Switzerland.ORCID 0000-0002-5988-0570
Hauke BuschInstitute for Experimental Dermatology, University of Lubeck, 23538 Lubeck, Germany.ORCID 0000-0003-4763-4521
Felicitas Bellutti EndersDivision of Pediatric Allergy, University Children's Hospital Basel, 4031 Basel, Switzerland.ORCID 0000-0001-6038-3814

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe prevalence of food allergy (FA) in children is increasing. Dysbiosis of the microbiome has been linked to FA but needs to be better understood. We aimed to characterize the gut and skin microbiome of young food-allergic children over time and within different types of immunoglobulin E (IgE)-mediated FA.

methodsWe studied 23 patients, as a pilot study of an ongoing prospective multicenter cohort study including children < 2y with newly diagnosed IgE-mediated FA. Samples (feces/skin swabs) were collected at enrollment and at 1-year follow-up and sequenced for the bacterial 16S rRNA gene (hypervariable v1-v2 region).

resultsGut and skin bacterial diversity was significantly higher in patients compared with controls and increased over time (beta test, Shannon diversity,

conclusionsThis study revealed an increased bacterial diversity in children with FA compared with non-atopic children. Importantly, the gut and skin microbiome differed in their composition over time and within different types of IgE-mediated FA. These findings contribute to the understanding of microbiome changes in children with FA and indicate the potential of the genus

Indexed as

Food HypersensitivityGastrointestinal MicrobiomeImmunoglobulin ESkinBacteriaChild, PreschoolDysbiosisFecesFemaleHumansInfantMaleMicrobiotaPilot ProjectsProspective StudiesRNA, Ribosomal, 16SImmunoglobulin ERNA, Ribosomal, 16Satopic dermatitisfecal microbiomeimmediate hypersensitivityinfantlongitudinalmicrobiotapaediatricpeanut allergypediatrictree nut allergy

Identifiers

PMID39599727
PMCPMC11597333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.