Evidence map›Paper›PMID 39599676›Full record

ArticleNutrients2024

Association of Low Protein-to-Carbohydrate Energy Ratio with Cognitive Impairment in Elderly Type 2 Diabetes Patients.

Antelm Pujol, Pilar Sanchis, María I Tamayo, Samantha Godoy, Pilar Andrés, Aleksandra Speranskaya, Ana Espino, Ana Estremera, Elena Rigo, Guillermo J Amengual and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Antelm PujolVascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0002-4579-4620
Pilar SanchisVascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0001-8565-1811
María I TamayoVascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Samantha GodoyLaboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Research Institute of Heath Science (IUNICS), Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Pilar AndrésNeuropsychology and Cognition, Department of Psychology, Research Institute of Heath Science (IUNICS), University of Balearic Islands, Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0003-2220-8198
Aleksandra SperanskayaVascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Ana EspinoNeurology Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.
Ana EstremeraNeuroradiology Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.
Elena RigoBalearic Research Group on Genetic Cardiopathies, Sudden Death, and TTR Amyloidosis, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Guillermo J AmengualNeuroradiology Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.
Manuel RodríguezNeuroradiology Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.
José Luis RibesClinical Analysis Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.
Isabel GomilaClinical Analysis Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.ORCID 0000-0001-7427-5312
Félix GrasesLaboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Research Institute of Heath Science (IUNICS), Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0001-5636-9139
Marta González-FreireTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0001-9741-2826
Lluís MasmiquelVascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.ORCID 0000-0002-6549-5652

Funding

Instituto de Salud Carlos III PI20/0471
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe relationship between macronutrient intake and cognitive decline in older adults with type 2 diabetes mellitus (T2DM) remains underexplored.

methodsThis cross-sectional study aimed to evaluate the association between the protein-to-carbohydrate energy ratio (%E:P) and cognitive impairment among 192 elderly T2DM patients. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and the Self-Administered Gerocognitive Exam (SAGE), while dietary intake data, including (%E:P), was gathered using a validated semi-quantitative food frequency questionnaire.

resultsParticipants had a mean age of 71 ± 6 years, 46.4% were female, and the median BMI was 30 ± 4 kg/m

conclusionsThese findings suggest that a lower (%E:P) ratio may be a risk factor for cognitive impairment in elderly T2DM patients. Monitoring this ratio may serve as an early detection tool for cognitive deterioration. Moreover, current protein intake recommendations for older adults with T2DM may be insufficient to prevent cognitive impairment. Further research is needed to establish optimal dietary guidelines for this population.

Indexed as

Cognitive DysfunctionDiabetes Mellitus, Type 2Dietary CarbohydratesDietary ProteinsAgedAged, 80 and overCognitionCross-Sectional StudiesDiet, Protein-RestrictedEnergy IntakeFemaleHumansMaleRisk FactorsDietary CarbohydratesDietary Proteinscognitive impairmentcognitive performancedietprotein intakeprotein-to-carbohydrate ratiotype 2 diabetes mellitus

Identifiers

PMID39599676
PMCPMC11597317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.