Evidence map›Paper›PMID 39599629›Full record

ArticleNutrients2024

Cannabidiol Enhances Mitochondrial Metabolism and Antioxidant Defenses in Human Intestinal Epithelial Caco-2 Cells.

Alejandro Bravo Iniguez, Qi Sun, Qiaorong Cui, Min Du, Mei-Jun Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alejandro Bravo IniguezSchool of Food Science, Washington State University, Pullman, WA 99164, USA.
Qi SunSchool of Food Science, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-5434-1324
Qiaorong CuiSchool of Food Science, Washington State University, Pullman, WA 99164, USA.
Min DuDepartment of Animal Sciences, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-7232-072X
Mei-Jun ZhuSchool of Food Science, Washington State University, Pullman, WA 99164, USA.

Funding

United States Department of Agriculture-National Institute of Food and Agriculture (USDA-NIFA) 2018-67017-27517Washington State University Agricultural Research Center Emerging Research Issues Competitive GrantWashington State University Dedicated Marijuana Account (DMAc) Grant
6 · The paper itself

Abstract

backgroundThe reintroduction of hemp production has resulted in increased consumption of cannabidiol (CBD) products, particularly CBD oil, yet their effects on intestinal health are not fully understood. Proper mitochondrial function and antioxidant defenses are vital for maintaining the intestinal epithelial barrier. AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator (PGC)1α are key mediators of mitochondrial metabolism. METHODS &

resultsUsing Caco-2 cells, we found that CBD oil promoted AMPK phosphorylation, upregulated differentiation markers, and enhanced PGC1α/SIRT3 mitochondrial signaling. CBD oil reduced reactive oxygen species production and increased antioxidant enzymes. Moreover, CBD oil also increased levels of citrate, malate, and succinate-key metabolites of the tricarboxylic acid cycle-alongside upregulation of pyruvate dehydrogenase and isocitrate dehydrogenase 1. Similarly, pure CBD induced metabolic and antioxidant signaling.

conclusionsCBD enhances mitochondrial metabolic activity and antioxidant defense in Caco-2 cells, making it a promising candidate for treating intestinal dysfunction.

Indexed as

AntioxidantsCannabidiolIntestinal MucosaMitochondriaAMP-Activated Protein KinasesCaco-2 CellsHumansOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphorylationReactive Oxygen SpeciesSignal TransductionSirtuin 3AMP-Activated Protein KinasesAntioxidantsCannabidiolPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanReactive Oxygen SpeciesSIRT3 protein, humanSirtuin 3AMPKantioxidant activitycannabidiolintestinal epitheliummitochondria

Identifiers

PMID39599629
PMCPMC11597683

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.