Evidence map›Paper›PMID 39599607›Full record

Trial reportNutrients2024

Comparison of Analgesic and Anti-Inflammatory Effects of Kale Extract Versus Ibuprofen After Impacted Mandibular Third Molar Surgery: A Randomized, Double-Blind Split-Mouth Clinical Trial.

Vuttinun Chatupos, Sansanee Neelawatanasook, Tidanut Sangutai, Atit Khanutwong, Pattaranee Srichairatanakool, Wachiraporn Tipsuwan, Onsaya Kerdto, Narisara Paradee, Pimpisid Koonyosying, Somdet Srichairatanakool

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vuttinun ChatuposDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Sansanee NeelawatanasookDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Tidanut SangutaiDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Atit KhanutwongDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Pattaranee SrichairatanakoolDepartment of Anesthesiology, School of Medicine, University of Phayao, Phayao 56000, Thailand.
Wachiraporn TipsuwanDivision of Biochemistry, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Onsaya KerdtoDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Narisara ParadeeDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Pimpisid KoonyosyingDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Somdet SrichairatanakoolDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-5706-8781

Funding

Distinguished Research Professor Somdet Srichairatanakool, PhD., National Research Council of Thailand N42A670732Royal Project Foundation, Chiang Mai 3055-A205
6 · The paper itself

Abstract

BACKGROUND/

objectiveWe assessed the analgesic and anti-inflammatory effects of kale extract (500 mg anthocyanin equivalent) in patients after mandibular molar surgery.

methodsIn our randomized clinical trial, postoperative subjects (n = 20) aged 18-25 years old took kale extract or ibuprofen (400 mg) capsules for 7 days, or vice versa, after surgical removal of each impacted tooth. Their pain intensity was then assessed using a visual analogue scale (VAS). Moreover, salivary α-amylase (AA) activity, matrix metalloproteinase 9 (MMP-9) and transforming growth factor beta2 (TGF-β

resultsThe kale extract was more effective than ibuprofen. MMP-9 and TGF-β

Indexed as

AnalgesicsAnti-Inflammatory AgentsBrassicaIbuprofenMolar, ThirdPlant ExtractsPostoperative PainTooth ExtractionTooth, ImpactedAdolescentAdultDouble-Blind MethodFemaleHumansMaleMandibleAnalgesicsAnti-Inflammatory AgentsIbuprofenMatrix Metalloproteinase 9Plant ExtractsTransforming Growth Factor beta2Brassica oleracea α-amylasekalematrix metalloproteinase 9third molarstransforming growth factor beta2visual analogue scale

Identifiers

PMID39599607
PMCPMC11597493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.