Evidence map›Paper›PMID 39599606›Full record

ArticleNutrients2024

Spatial Transcriptomics and Single-Nucleus Multi-Omics Analysis Revealing the Impact of High Maternal Folic Acid Supplementation on Offspring Brain Development.

Xiguang Xu, Yu Lin, Liduo Yin, Priscila da Silva Serpa, Benjamin Conacher, Christina Pacholec, Francisco Carvallo, Terry Hrubec, Shannon Farris, Kurt Zimmerman and 2 more

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Xiguang XuEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0001-6862-7545
Yu LinEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Liduo YinEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0003-2310-9511
Priscila da Silva SerpaDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0001-6073-2172
Benjamin ConacherEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Christina PacholecDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Francisco CarvalloDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Terry HrubecDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Shannon FarrisDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Kurt ZimmermanDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Xiaobin WangCenter on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0003-4451-302X
Hehuang XieEpigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0001-5739-1653

Funding

Functional RNA Modifications, Micronutrient Exposure, Developmental DisabilitiesR01ES031521 · NIEHS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, XIAOBIN, XIE, HEHUANG · 2020 to 2024
$1.9M
The epigenetic role of EGR1 during postnatal brain development and in neuronal activityR01NS094574 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI XIE, HEHUANG · 2016 to 2020
$1.7M
Exploring epigenetic regulation of memory extinctionR21MH120498 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JAROME, TIMOTHY JOSEPH, XIE, HEHUANG · 2020 to 2020
$419k
NIEHS NIH HHS R01 ES031521NIH HHS ES031521NIH HHS MH120498NIH HHS NS094574NIMH NIH HHS R21 MH120498NINDS NIH HHS R01 NS094574NSF NSF1922428
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BrainDietary SupplementsFolic AcidNeurogenesisTranscriptomeAnimalsFemaleGene Expression ProfilingMaleMaternal Nutritional Physiological PhenomenaMiceMice, Inbred C57BLMultiomicsPregnancyPrenatal Exposure Delayed EffectsFolic Acidbrain developmentfolic acidhippocampussingle-nucleus multi-omicsspatial transcriptomics

Identifiers

PMID39599606
PMCPMC11597041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.