ArticleNutrients2024
Vitamin D Deficiency: Insights and Perspectives from a Five-Year Retrospective Analysis of Children from Northeastern Romania.
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modifiable Nutritional Biomarkers in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Vitamin D, BInternational journal of molecular sciences · 2025Pooled it
- Article
- Associations Between Serum 25(OH)D Concentrations and Clinical Characteristics in Pediatric Patients.Reports (MDPI) · 2026Article
- Vitamin D Status in Children: Romania's National Vitamin D Screening Programme in Context of the COVID-19 Pandemic.Medical sciences (Basel, Switzerland) · 2025Observational
- Vitamin D Deficiency and Its Role in Pathologies of Oxidative Stress: A Literature Review.Cureus · 2025Review
- Retrospective Serologic Assessment of Vitamin D Levels in Children from Western Romania: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
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Abstract
backgroundVitamin D plays an important role in maintaining bone health with numerous benefits for extraskeletal health as well.
objectivesWe aimed to assess the prevalence of vitamin D deficiency in children (0-18 years old) in a tertiary hospital in Romania between August 2019 and January 2024 and to investigate the role of adequate supplementation in this vulnerable population.
methodsThe serum 25(OH)D levels were measured using a chemiluminescence binding assay.
resultsA total of 744 participants were included in this study: 396 female (53.23%) and 348 male (46.77%). The serum levels of 25(OH)D ranged between 2.2 and 125.4 ng/mL, with a mean value of 27.4 ng/mL and a median value of 23.5 ng/mL. According to the cutoff values for the definition of vitamin D status (severe deficiency: <10 ng/mL, deficiency: <20 ng/mL, insufficiency: 20-29 ng/mL, and sufficiency: ≥30 ng/mL), the sample consisted of 77 (10.34%) cases of severe deficiency, 221 (29.7%) cases of deficiency, 194 (26.07%) cases of insufficiency, and 245 (32.93%) cases of sufficiency. There were seven cases of hypervitaminosis D with values above 100 ng/mL. The mean values (and corresponding 95% confidence intervals, CIs) were as follows: 27.85 ng/mL [25.95-29.76] in the males, 22.45 ng/mL [25.12-28.82] in the females, 24.82 ng/mL [21.86-27.77] in the spring, 28.62 ng/mL [26.42-30.81] in the summer, 32.30 ng/mL [29.16-35.44] in the autumn, and 24.01 ng/mL [21.57-26.44] in the winter. We observed a notable decline in the serum 25(OH)D levels with age, with 82.08% of the children in the age group above 6 years old having serum 25(OH)D levels below 30 ng/mL. In obese subjects, a higher prevalence of hypovitaminosis D was observed compared to non-obese subjects, with a mean value of 19.54 [17.50-21.57] ng/mL in obese children versus 28.89 [27.39-30.40] ng/mL in normal weight children.
conclusionsIn our sample, the mean serum concentration of 25(OH)D was 27.4 ng/mL. Notably, 66.11% of the cases demonstrated varying degrees of hypovitaminosis D, with a significantly higher prevalence of 86.16% observed in the obese group. Healthcare providers should prioritize routine screening for vitamin D levels in pediatric patients with obesity to facilitate timely intervention and personalized supplementation strategies tailored to individual needs.
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