Evidence map›Paper›PMID 39599546›Full record

ArticlePathogens (Basel, Switzerland)2024

Burden and Risk Factors for Coinfections in Patients with a Viral Respiratory Tract Infection.

Pierachille Santus, Fiammetta Danzo, Juan Camilo Signorello, Alberto Rizzo, Andrea Gori, Spinello Antinori, Maria Rita Gismondo, Anna Maria Brambilla, Marco Contoli, Giuliano Rizzardini and 1 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pierachille SantusDivision of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), Università Degli Studi di Milano, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, 20147 Milano, Italy.ORCID 0000-0003-3462-8253
Fiammetta DanzoDivision of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), Università Degli Studi di Milano, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, 20147 Milano, Italy.
Juan Camilo SignorelloDivision of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), Università Degli Studi di Milano, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, 20147 Milano, Italy.
Alberto RizzoLaboratory of Clinical Microbiology, Virology and Bioemergencies-ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, 20157 Milano, Italy.ORCID 0000-0001-5999-006X
Andrea GoriDepartment of Infectious Diseases, L. Sacco University Hospital, ASST Fatebenefratelli-Sacco, 20122 Milano, Italy.ORCID 0000-0001-6587-4794
Spinello AntinoriIII Division of Infectious Diseases, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milano, Italy.ORCID 0000-0003-0569-9407
Maria Rita GismondoClinical Microbiology, Virology and Bioemergency Diagnostics, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, 20157 Milano, Italy.
Anna Maria BrambillaEmergency Medicine Unit, Luigi Sacco University Hospital, ASST Fatebenefratelli-Sacco, 20157 Milano, Italy.
Marco ContoliRespiratory Section, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-2731-5809
Giuliano RizzardiniI Division of Infectious Diseases, Luigi Sacco University Hospital, ASST Fatebenefratelli-Sacco, 20157 Milano, Italy.
Dejan RadovanovicDivision of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), Università Degli Studi di Milano, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, 20147 Milano, Italy.ORCID 0000-0002-9013-3418

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Which patients should be monitored for coinfections or should receive empirical antibiotic treatment, in patients with an acute viral respiratory infection, is largely unknown. We evaluated the prevalence, characteristics, outcomes of coinfected patients, and risk factors associated with a coinfection among patients with an acute viral infection. A retrospective, single-center study recruited consecutive patients from October 2022 to March 2023 presenting to the emergency department with signs of a respiratory tract infection. Patients were screened for respiratory viruses and bacterial/fungal secondary infections according to local standard procedures. Outcomes included severe disease, in-hospital complications, all-cause in-hospital and ICU-related mortality, time to death, time to discharge, and time to coinfection. The analysis included 652 patients. A viral infection and a secondary bacterial/fungal infection were detected in 39.1% and 40% of cases. Compared with the rest of the cohort, coinfected patients had more frequently severe disease (88.3%,

Indexed as

CoinfectionCOVID-19Respiratory Tract InfectionsAdultAgedBacterial InfectionsFemaleHospital MortalityHumansMaleMiddle AgedMycosesPrevalenceRetrospective StudiesRisk FactorsSARS-CoV-2coinfectioninfluenzamortalitymultidrug resistantrespiratory syncytial virusSARS-CoV-2

Identifiers

PMID39599546
PMCPMC11597400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.