Evidence map›Paper›PMID 39599514›Full record

ArticlePathogens (Basel, Switzerland)2024

Exploring Antibacterial Usage and Pathogen Surveillance over Five Years in a Tertiary Referral Teaching Hospital Adult General Intensive Care Unit (ICU).

David Young, Cathrine A McKenzie, Sanjay Gupta, David Sparkes, Ryan Beecham, David Browning, Ahilanandan Dushianthan, Kordo Saeed

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David YoungPharmacy Department, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0003-0102-5739
Cathrine A McKenzieNational Institute of Health and Social Care Research (Biomedical Research Centre Southampton Perioperative and Critical Care Theme), Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
Sanjay GuptaGeneral Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
David SparkesGeneral Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Ryan BeechamGeneral Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
David BrowningMicrobiology Department, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Ahilanandan DushianthanNational Institute of Health and Social Care Research (Biomedical Research Centre Southampton Perioperative and Critical Care Theme), Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0002-0165-3359
Kordo SaeedNational Institute of Health and Social Care Research (Biomedical Research Centre Southampton Perioperative and Critical Care Theme), Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0003-0123-0302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a globally recognised health emergency. Intensive care is an area with significant antimicrobial consumption, particularly increased utilisation of broad-spectrum antibacterials, making stewardship programmes essential. We aimed to explore antibacterial consumption, partnered with pathogen surveillance, over a five-year period (2018 to 2023) in a tertiary referral adult general intensive care unit (ICU). The mean number of admissions was 1645 per annum. A comparison between the ICU populations admitted before and after the COVID-19 pandemic peak (2020/21) identified several notable differences with increased average daily unit bed occupancy (21.6 vs. 25.2, respectively) and a higher proportion of admissions with sepsis (28.4% vs. 32.5%, respectively) in the post-pandemic period. Over the entire five years, the overall proportion of antibacterial use by the WHO AWaRe classification was 42.6% access, 54.7% watch and 2.6% reserve. One hundred and forty-seven positive blood culture isolates were reported, with the most concerning antibacterial resistance identified in 7.5% (9

Indexed as

Anti-Bacterial AgentsCOVID-19Hospitals, TeachingIntensive Care UnitsTertiary Care CentersAdultAgedAntimicrobial StewardshipDrug Resistance, BacterialFemaleHumansKlebsiella pneumoniaeMaleMiddle AgedPandemicsSARS-CoV-2Anti-Bacterial Agentsantibacterial consumptionantimicrobial stewardshipCOVID-19 pandemicpathogen surveillance

Identifiers

PMID39599514
PMCPMC11597157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.