Evidence map›Paper›PMID 39599472›Full record

ArticlePathogens (Basel, Switzerland)2024

Radiological Changes in the Spinal Cord and Brain of Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).

Emily H Stack, Serhat V Okar, Tianxia Wu, Mallory Stack, Yair Mina, María Gaitán, Shila Azodi, Will Frazier, Joan Ohayon, Irene C M Cortese and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. High-Field-Blinded Assessment of Portable Ultra-Low-Field Brain MRI for Multiple Sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emily H StackViral Immunology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0009-0008-0115-7321
Serhat V OkarTranslational Neuroradiology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0003-3716-2196
Tianxia WuClinical Trials Unit, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Mallory StackViral Immunology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Yair MinaViral Immunology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0003-2311-6623
María GaitánTranslational Neuroradiology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Shila AzodiViral Immunology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Will FrazierViral Immunology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Joan OhayonNeuroimmunology Clinic, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Irene C M CorteseNeuroimmunology Clinic, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Daniel S ReichTranslational Neuroradiology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-2628-4334
Govind NairqMRI Core, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0003-3725-615X
Steven JacobsonViral Immunology Section, NINDS, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

Funding

Intramural Research Program at National Institutes of Health Z
6 · The paper itself

Abstract

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neurological disorder and shares many radiological and clinical features with other more prevalent myelopathies. Here, we quantified spinal cord and brain volumes in adults with HAM/TSP in comparison with healthy volunteers (HVs) and individuals diagnosed with relapsing-remitting or progressive multiple sclerosis (RRMS or P-MS). Clinical disability and MRI were assessed in 24 HVs, 43 HAM/TSP subjects, and 46 MS subjects. Spinal cord cross-sectional area (SCCSA) and brain tissue volumes were measured and compared. HAM/TSP subjects had significantly lower SCCSA corresponding to cervical levels 2 and 3 (C2-3) (54.0 ± 8 mm

Indexed as

BrainMagnetic Resonance ImagingParaparesis, Tropical SpasticSpinal CordAdultAgedFemaleHumansHuman T-lymphotropic virus 1MaleMiddle AgedWhite Mattercentral nervous system atrophyHTLV-1-associated myelopathymagnetic resonance imagingspinal cord atrophywhite matter hyperintensities

Identifiers

PMID39599472
PMCPMC11597248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.