Evidence map›Paper›PMID 39599345›Full record

ArticlePlants (Basel, Switzerland)2024

Chokeberry Products and By-Products as the Potential Pharmaceuticals for Kidney Protection-An Experimental Study in Rats.

Milica Milutinović, Nada Ćujić Nikolić, Tatjana Cvetković, Katarina Šavikin, Ivana Djordjević, Ljubinka Janković Veličković, Milica Randjelović, Bojana Miladinović, Suzana Branković, Dušanka Kitić

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Bioactivity ofPlants (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Milica MilutinovićDepartment of Pharmacy, Faculty of Medicine, University of Niš, Bul. Dr Zorana Đinđića 81, 18000 Niš, Serbia.ORCID 0000-0002-9895-3840
Nada Ćujić NikolićInstitute of Medicinal Plants Research, Dr Josif Pančić, Tadeuša Koščuška 1, 11000 Beograd, Serbia.ORCID 0000-0002-6736-3637
Tatjana CvetkovićInstitute of Biochemistry, Faculty of Medicine, University of Niš, Bul. Dr Zorana Đinđića 81, 18000 Niš, Serbia.
Katarina ŠavikinInstitute of Medicinal Plants Research, Dr Josif Pančić, Tadeuša Koščuška 1, 11000 Beograd, Serbia.
Ivana DjordjevićPathology and Pathological Anatomy Center, University Clinical Centre, Bul. Dr Zorana Đinđića 48, 18000 Niš, Serbia.
Ljubinka Janković VeličkovićPathology and Pathological Anatomy Center, University Clinical Centre, Bul. Dr Zorana Đinđića 48, 18000 Niš, Serbia.
Milica RandjelovićDepartment of Pharmacy, Faculty of Medicine, University of Niš, Bul. Dr Zorana Đinđića 81, 18000 Niš, Serbia.ORCID 0000-0002-6951-9957
Bojana MiladinovićDepartment of Pharmacy, Faculty of Medicine, University of Niš, Bul. Dr Zorana Đinđića 81, 18000 Niš, Serbia.ORCID 0000-0003-2880-6519
Suzana BrankovićDepartment of Physiology, Faculty of Medicine, University of Niš, Bul. Dr Zorana Đinđića 81, 18000 Niš, Serbia.ORCID 0009-0005-1814-9844
Dušanka KitićDepartment of Pharmacy, Faculty of Medicine, University of Niš, Bul. Dr Zorana Đinđića 81, 18000 Niš, Serbia.ORCID 0000-0001-8551-274X

Funding

Internal Project of the Faculty of Medicine, University of Niš, Serbia 68Ministry of Education, Science and Technological Development of the Republic of Serbia 451-03-65/2024-03/200113 and 451-03-66/2024-03/200003
6 · The paper itself

Abstract

The study aimed to investigate the protective effects of chokeberry fruit products and by-products against cisplatin-induced acute nephrotoxicity in rats. Potential mechanisms involving oxidative stress and inflammatory responses were examined through biochemical and histopathological analyses of kidney tissue. Chokeberry waste, along with the whole fruit extract and juice, was evaluated as a potential raw material for pharmaceutical use. The chemical composition of chokeberry juice and extracts was analyzed using spectrophotometry and HPLC. Rats were treated with chokeberry preparations via intragastric tube for ten days, with a single intraperitoneal dose of cisplatin (8 mg/kg BW) administered on the third day. Post-sacrifice, plasma samples were analyzed for biochemical nephrotoxicity markers, oxidative stress, and inflammatory markers. Kidneys were removed for histopathological and biochemical analysis. Cisplatin-induced acute nephrotoxicity was confirmed by elevated plasma creatinine and blood urea nitrogen levels. Additionally, lipid peroxidation was significantly elevated, while reduced glutathione and catalase activity were significantly reduced. Pro-inflammatory mediators IL-1

Indexed as

chokeberry fruitcisplatin-induced nephrotoxicityextracthistopathological examinationinflammatory markersjuiceoxidative stress markersratswaste by-products

Identifiers

PMID39599345
PMCPMC11597244

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.