ArticlePolymers2024
Development of Antioxidant-Active Sericin-Curcumin-Loaded Sodium Alginate/Polyvinyl Alcohol Films Crosslinked with Calcium Chloride as a Promising Wound Dressing Application.
Article in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Development and Evaluation of Curcumin-Loaded Mucoadhesive Buccal Films Using Green Deep Eutectic Solvents via Design of Experiments.Pharmaceutics · 2026Article
- Silk sericin and its biomedical applications: extraction methods, genetic insights (Ser1-Ser6), and developments of multifunctional biomaterials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- A Numerical Study on the Drug Release Process of Biodegradable Polymer Drug-Loaded Vascular Stents.Polymers · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Silk sericin (SS) and curcumin (Cur) possess significant antioxidant properties, making them highly beneficial for wound healing applications. This study aimed to develop SS-Cur-loaded sodium alginate/polyvinyl alcohol (SA/PVA) films crosslinked with calcium chloride, creating a biomaterial with enhanced stability and antioxidant properties. Wound dressings containing SS-Cur were fabricated by mixing SA and PVA at different ratios of 1:1, 1:2, 1:4, and 1:6. The resulting films were then crosslinked with calcium chloride in an ethanol solution to enhance film integrity. These films were characterized using several techniques, revealing that the presence of ethanol in calcium chloride affected film properties, including the gel fraction, swelling, film thickness, and FTIR analysis. The presence of ethanol in calcium chloride revealed the highest drug content in the SA/PVA films. In vitro release studies demonstrated sustained release of SS-Cur from all formulations. Cytotoxicity and antioxidant activity tests showed that SS-Cur-loaded SA/PVA films with ethanol in calcium chloride increased cell viability and enhanced antioxidant effects in L929 cells. In conclusion, this study demonstrates that the presence of ethanol in the crosslinking solution improved the functionality of SS-Cur-loaded SA/PVA films, making them promising candidates for wound healing and soft tissue regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.