Towards a General Method for Using Cyclotron-Produced Ga68 to Manufacture Clinical and Research Ga68 Tracers.

Ivan E Wang, Kevin Cheng, Allen F Brooks, Peter J H Scott, Benjamin L Viglianti

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

[Current radiopharmaceuticals · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ivan E WangDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, 1301 Catherine St. 2276 Medical Science I, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1318-9522

Kevin ChengDivision of Nuclear Medicine, Department of Radiology, University of Michigan, 1301 Catherine St. 2276 Medical Science I, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9728-2953

Allen F BrooksDivision of Nuclear Medicine, Department of Radiology, University of Michigan, 1301 Catherine St. 2276 Medical Science I, Ann Arbor, MI 48109, USA.

Peter J H ScottDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, 1301 Catherine St. 2276 Medical Science I, Ann Arbor, MI 48109, USA.

Benjamin L VigliantiDivision of Nuclear Medicine, Department of Radiology, University of Michigan, 1301 Catherine St. 2276 Medical Science I, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8471-4988

Funding

Synthesis of Novel PET Radiotracers for Imaging in Alzheimer’s Disease and Related DisordersR01EB021155 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANFORD, MELANIE S., SCOTT, PETER JAMES HENRY · 2016 to 2024

$3.2M

NERTF 1159892NIBIB NIH HHS R01 EB021155NIH HHS 1R01EB021155-01A1

6 · The paper itself

Abstract

The success of multiple nuclear medicine radiotherapeutics in treating cancer requires an increased supply of companion diagnostic imaging agents radiolabeled with gallium-68. Cyclotron production addresses the need for access to gallium-68 and has been validated for use with commercially produced sterile kits. For novel research tracers undergoing translational studies (IND or RDRC), developing and purchasing sterile kits is time- and cost-prohibitive. An on-cassette labeling method with terminal filtration allows non-sterile kits to be fabricated in-house, simplifying workflow and allowing multiple PET imaging agents to be evaluated using the same kit (i.e., parts, reagents, and timelist) with minimal variation. Using modified GE gallium chloride cassettes, four diverse clinically relevant tracers (DOTA-TOC, FAPI-04, pentixafor, and PSMA-11) were radiolabeled with gallium-68 to evaluate the approach using DOTA and HBED-CC chelator types. The tracers were all formulated according to established FDA-approved formulations and sterile-filtered using a PVDF membrane. The automated procedure is robust, tolerating DOTA and HBED-CC chelators, and can be used to screen numerous gallium-68 agents for rapid translation to clinical use.

Indexed as

CyclotronsGallium RadioisotopesRadiopharmaceuticalsHumansPositron-Emission TomographyGallium-68Gallium RadioisotopesRadiopharmaceuticalscyclotronFAPIgalliumpentixafor

Identifiers

PMID39598846

DOI10.3390/molecules29225457

PMCPMC11597648

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.