Evidence map›Paper›PMID 39598823›Full record

ArticleMolecules (Basel, Switzerland)2024

Study of Endocrine-Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE-MILCH PROJECT.

Francesca Nuti, Feliciana Real Fernández, Mirko Severi, Rita Traversi, Vassilios Fanos, Maria Elisabeth Street, Paola Palanza, Paolo Rovero, Anna Maria Papini

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca NutiInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology (Peptlab) and Centre of Competences in Molecular Diagnostics and Life Sciences (MoD&LS), University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-9908-5996
Feliciana Real FernándezInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology (Peptlab) and Centre of Competences in Molecular Diagnostics and Life Sciences (MoD&LS), University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-5747-2285
Mirko SeveriDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-1511-6762
Rita TraversiDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-9790-2195
Vassilios FanosSection of Neonatal Intensive Care Unit, Department of Paediatrics, Puericulture Institute and Neonatal Section, Azienda Mista and University of Cagliari, 09124 Cagliari, Italy.
Maria Elisabeth StreetDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0001-8427-8971
Paola PalanzaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-2873-4260
Paolo RoveroInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology (Peptlab) and Centre of Competences in Molecular Diagnostics and Life Sciences (MoD&LS), University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-9577-5228
Anna Maria PapiniInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology (Peptlab) and Centre of Competences in Molecular Diagnostics and Life Sciences (MoD&LS), University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-2947-7107

Funding

European Union LIFE18 ENV/IT/00460 - Life MILCH
6 · The paper itself

Abstract

Exposure to endocrine-disrupting chemicals (EDCs) is inevitable, and growing scientific evidence indicates that even very low doses can negatively impact human health, particularly during pregnancy and the neonatal period. As part of the European project LIFE18 ENV/IT/00460, this study aims to identify the presence of EDCs in 20 infant formulas (both powdered and liquid) and the release from baby bottles and teats. Particularly, sensitization of young people and future parents towards the potential harmful effects of EDCs could significantly help to reduce exposure. Seven different UPLC-MS/MS methodologies and one ICP-AES were set up to quantify already assessed and suspected EDCs among 85 different chemicals (bisphenols, parabens, PAHs, phthalates, pesticides, herbicides and their main metabolites, PFAS, and metals). Results showed that in 2 out of 14 baby bottles, only anthracene and phenanthrene of the group of PAHs were released (10.68-10.81 ng/mL). Phthalates such as mono-ethyl phthalate (MEP) were found in 9 of 14 samples (0.054-0.140 ng/mL), while mono(2-ethyl-5-oxohexyl) phthalate (MeOHP) appeared in 2 samples (0.870-0.930 ng/mL). In accordance with current EU regulations, other chemicals were not detected in baby bottles and teats. However, bisphenols, parabens, PAHs, phthalates, PFAS, and metals were detected in infant formula, emphasizing the need for continued monitoring and public health interventions.

Indexed as

Endocrine DisruptorsInfant FormulaEuropeHumansInfantInfant, NewbornPhthalic AcidsTandem Mass SpectrometryEndocrine DisruptorsPhthalic Acidsbaby bottlesbiomarkersbisphenolsendocrine-disrupting chemicalsheavy metalsinfant formulaphthalates

Identifiers

PMID39598823
PMCPMC11597460

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.