Evidence map›Paper›PMID 39598664›Full record

ReviewMolecules (Basel, Switzerland)2024

Cytotoxic Effects of Plant Secondary Metabolites and Naturally Occurring Bioactive Peptides on Breast Cancer Model Systems: Molecular Mechanisms.

Diana Zasheva, Petko Mladenov, Silvina Zapryanova, Zlatina Gospodinova, Mariyana Georgieva, Irina Alexandar, Valentin Velinov, Dimitar Djilianov, Daniela Moyankova, Lyudmila Simova-Stoilova

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Lipophilic Extracts ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Diana ZashevaInstitute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Tsarigradsko Shosse, 73, 1113 Sofia, Bulgaria.
Petko MladenovAgrobioinstitute, Agricultural Academy, bul. "Dragan Tsankov" 8, 1164 Sofia, Bulgaria.
Silvina ZapryanovaInstitute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Tsarigradsko Shosse, 73, 1113 Sofia, Bulgaria.ORCID 0009-0007-2533-9835
Zlatina GospodinovaInstitute of Plant Physiology and Genetics, Bulgarian Academy of Science, "Acad. Georgi Bonchev" Str., Bl. 21, 1113 Sofia, Bulgaria.ORCID 0000-0001-7976-7631
Mariyana GeorgievaInstitute of Plant Physiology and Genetics, Bulgarian Academy of Science, "Acad. Georgi Bonchev" Str., Bl. 21, 1113 Sofia, Bulgaria.ORCID 0000-0002-4268-002X
Irina AlexandarInstitute of Molecular Biology "Rumen Tzanev", Bulgarian Academy of Sciences, "Acad. Georgi Bonchev" Str., Bl. 21, 1113 Sofia, Bulgaria.
Valentin VelinovInstitute of Plant Physiology and Genetics, Bulgarian Academy of Science, "Acad. Georgi Bonchev" Str., Bl. 21, 1113 Sofia, Bulgaria.
Dimitar DjilianovAgrobioinstitute, Agricultural Academy, bul. "Dragan Tsankov" 8, 1164 Sofia, Bulgaria.ORCID 0000-0001-6492-8033
Daniela MoyankovaAgrobioinstitute, Agricultural Academy, bul. "Dragan Tsankov" 8, 1164 Sofia, Bulgaria.ORCID 0000-0003-4020-1918
Lyudmila Simova-StoilovaInstitute of Plant Physiology and Genetics, Bulgarian Academy of Science, "Acad. Georgi Bonchev" Str., Bl. 21, 1113 Sofia, Bulgaria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the second leading cause of death among women, and the number of mortal cases in diagnosed patients is constantly increasing. The search for new plant compounds with antitumor effects is very important because of the side effects of conventional therapy and the development of drug resistance in cancer cells. The use of plant substances in medicine has been well known for centuries, but the exact mechanism of their action is far from being elucidated. The molecular mechanisms of cytotoxicity exerted by secondary metabolites and bioactive peptides of plant origin on breast cancer cell lines are the subject of this review.

Indexed as

Breast NeoplasmsPeptidesAntineoplastic Agents, PhytogenicCell Line, TumorFemaleHumansPlant ExtractsPlantsSecondary MetabolismAntineoplastic Agents, PhytogenicPeptidesPlant Extractsbioactive peptidesbreast cancercytotoxicityMCF7MDA-MB231secondary metabolites

Identifiers

PMID39598664
PMCPMC11596968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.