Substrate Specificity of ABCB Transporters Predicted by Docking Simulations Can Be Confirmed by Experimental Tests.

Mario Röpcke, Sha Lu, Cäcilia Plate, Fee Meinzer, Antonia Lisiecki, Susanne Dobler

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mario RöpckeInstitute of Cell and System Biology of Animals, Universität Hamburg, 20146 Hamburg, Germany.ORCID 0009-0001-6264-3744

Sha LuInstitute of Cell and System Biology of Animals, Universität Hamburg, 20146 Hamburg, Germany.

Cäcilia PlateInstitute of Cell and System Biology of Animals, Universität Hamburg, 20146 Hamburg, Germany.

Fee MeinzerInstitute of Cell and System Biology of Animals, Universität Hamburg, 20146 Hamburg, Germany.

Antonia LisieckiInstitute of Cell and System Biology of Animals, Universität Hamburg, 20146 Hamburg, Germany.

Susanne DoblerInstitute of Cell and System Biology of Animals, Universität Hamburg, 20146 Hamburg, Germany.ORCID 0000-0002-0635-7719

Funding

Deutsche Forschungsgemeinschaft Do527/11-1

6 · The paper itself

Abstract

ATP-binding cassette (ABC) transporters, particularly those of subfamily B, are involved in cell detoxification, multidrug resistance, drug treatment pharmacodynamics, and also ecological adaptation. In this regard, ABCB transporters may play a decisive role in the co-evolution between plants and herbivores. Cardenolides, toxic steroid glycosides, are secondary plant metabolites that defend plants against herbivores by targeting their sodium-potassium ATPase. Despite their toxicity, several herbivorous insects such as the large milkweed bug (

Indexed as

Molecular Docking SimulationAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BBinding SitesCardenolidesProtein BindingSubstrate SpecificityATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BCardenolidesATPase activity assaysATP-binding cassette (ABC) transportercardenolidesco-evolutionary relationshipsdocking simulationslarge milkweed bugOncopeltus fassciatussubstrate specificityVinavirtual ligand screening

Identifiers

PMID39598661

DOI10.3390/molecules29225272

PMCPMC11596062

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.