Evidence map›Paper›PMID 39598627›Full record

ArticleMolecules (Basel, Switzerland)2024

Affordable Small Molecules as Promising Fluorescent Labels for Biomolecules.

Raquel Eustáquio, João P Prates Ramalho, Sílvia Arantes, António Candeias, Ana Teresa Caldeira, António Pereira

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raquel EustáquioHERCULES Laboratory, IN2PAST-Associate Laboratory for Research and Innovation in Heritage, Arts, Sustainability and Territory, University of Évora, Largo Marquês de Marialva 8, 7000-809 Évora, Portugal.ORCID 0000-0002-2919-7295
João P Prates RamalhoHERCULES Laboratory, IN2PAST-Associate Laboratory for Research and Innovation in Heritage, Arts, Sustainability and Territory, University of Évora, Largo Marquês de Marialva 8, 7000-809 Évora, Portugal.ORCID 0000-0003-4419-6431
Sílvia ArantesHERCULES Laboratory, IN2PAST-Associate Laboratory for Research and Innovation in Heritage, Arts, Sustainability and Territory, University of Évora, Largo Marquês de Marialva 8, 7000-809 Évora, Portugal.ORCID 0000-0001-8779-9828
António CandeiasHERCULES Laboratory, IN2PAST-Associate Laboratory for Research and Innovation in Heritage, Arts, Sustainability and Territory, University of Évora, Largo Marquês de Marialva 8, 7000-809 Évora, Portugal.
Ana Teresa CaldeiraHERCULES Laboratory, IN2PAST-Associate Laboratory for Research and Innovation in Heritage, Arts, Sustainability and Territory, University of Évora, Largo Marquês de Marialva 8, 7000-809 Évora, Portugal.ORCID 0000-0001-5409-6990
António PereiraHERCULES Laboratory, IN2PAST-Associate Laboratory for Research and Innovation in Heritage, Arts, Sustainability and Territory, University of Évora, Largo Marquês de Marialva 8, 7000-809 Évora, Portugal.ORCID 0000-0002-9553-1618

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescent labels, commonly used in highly sensitive analytical techniques for detecting and tracking biomolecules in critical fields like cellular biology, medicine, medicinal chemistry, and environmental science, are currently too expensive for routine use in standard applications, with most exhibiting small Stokes shifts. This limitation underscores the potential of 4-diethylaminobenzaldehyde derivatives as a cost-effective alternative for developing new, bright fluorophores with larger Stokes shifts. In this work, using 4-diethylaminobenzaldehyde as starting material, we developed a simple, cost-effective, and efficient synthetic strategy to produce new affordable small molecules as effective fluorescent labels for biomolecules. Density functional theory and time-dependent density functional theory calculations were also conducted to gain insights into the observed photophysical properties.

Indexed as

Fluorescent DyesBenzaldehydesDensity Functional TheoryMolecular StructureSmall Molecule LibrariesBenzaldehydesFluorescent DyesSmall Molecule Libraries4-diethylaminobenzaldehyde derivativesbiomoleculesfluorescent labelsRNA-FISH probes

Identifiers

PMID39598627
PMCPMC11596234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.