Evidence map›Paper›PMID 39598600›Full record

ArticlePharmaceutics2024

Antitubercular Activity of 7-Methyljuglone-Loaded Poly-(Lactide Co-Glycolide) Nanoparticles.

Bianca Diedericks, Anna-Mari Kok, Vusani Mandiwana, Bhavna Gowan Gordhan, Bavesh Davandra Kana, Suprakas Sinha Ray, Namrita Lall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bianca DiedericksDepartment of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa.ORCID 0000-0002-1707-3201
Anna-Mari KokDepartment of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa.ORCID 0000-0002-4552-4022
Vusani MandiwanaCentre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.
Bhavna Gowan GordhanNational Health Laboratory Service, School of Pathology, Faculty of Health Science, University of the Witwatersrand, Johannesburg 2000, South Africa.
Bavesh Davandra KanaNational Health Laboratory Service, School of Pathology, Faculty of Health Science, University of the Witwatersrand, Johannesburg 2000, South Africa.
Suprakas Sinha RayCentre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.ORCID 0000-0002-0007-2595
Namrita LallDepartment of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa.

Funding

National Research Foundation 98334
6 · The paper itself

Abstract

BACKGROUND/

objectivesLoading of natural products into poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as drug delivery systems for the treatment of diseases, such as tuberculosis (TB), has been widely explored. The current study investigated the use of PLGA nanoparticles with 7-methyljuglone (7-MJ), an active pure compound, isolated from the roots of

methods7-MJ as well as its respective PLGA nanoparticles were tested for their antimycobacterial activity against

results7-MJ has been shown to have a minimum inhibitory concentration (MIC) value of 1.6 µg/mL against

conclusionsThe results of this study suggested the possibility of improved delivery during TB therapy via the use of PLGA nanoparticles.

Indexed as

7-methyljugloneantimycobacterialcytotoxicitynanoparticlepoly-(lactide-co-glycolide)tuberculosis

Identifiers

PMID39598600
PMCPMC11597334

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.