Evidence map›Paper›PMID 39598597›Full record

ArticlePharmaceutics2024

Improving the Theranostic Potential of Magnetic Nanoparticles by Coating with Natural Rubber Latex for Ultrasound, Photoacoustic Imaging, and Magnetic Hyperthermia: An In Vitro Study.

Thiago T Vicente, Saeideh Arsalani, Mateus S Quiel, Guilherme S P Fernandes, Keteryne R da Silva, Sandra Y Fukada, Alexandre J Gualdi, Éder J Guidelli, Oswaldo Baffa, Antônio A O Carneiro and 2 more

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In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thiago T VicenteDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.
Saeideh ArsalaniDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.
Mateus S QuielDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.
Guilherme S P FernandesDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.ORCID 0000-0002-4105-7631
Keteryne R da SilvaDepartment of BioMolecular Sciences, FCFRP, University of São Paulo, Av. Professor Doutor Zeferino Vaz, sn, Ribeirão Preto 14040-901, São Paulo, Brazil.
Sandra Y FukadaDepartment of BioMolecular Sciences, FCFRP, University of São Paulo, Av. Professor Doutor Zeferino Vaz, sn, Ribeirão Preto 14040-901, São Paulo, Brazil.
Alexandre J GualdiDepartment of Physics, Federal University of São Carlos, Rod. Washington Luiz, km 235, São Carlos 13565-905, São Paulo, Brazil.ORCID 0000-0002-6127-9610
Éder J GuidelliDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.
Oswaldo BaffaDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.ORCID 0000-0002-0622-2814
Antônio A O CarneiroDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.ORCID 0000-0002-1752-7170
Ana Paula RamosDepartment of Chemistry, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.ORCID 0000-0001-6200-8989
Theo Z PavanDepartment of Physics, FFCLRP, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-901, São Paulo, Brazil.ORCID 0000-0002-9931-8558

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/06728-2 2018/16939-8 2017/14482-8 2013/18854-6 2013/07699-0National Council for Scientific and Technological Development 311224/2021-0 305827/2023-5
6 · The paper itself

Abstract

BACKGROUND/

objectivesMagnetic nanoparticles (MNPs) have gained attention in theranostics for their ability to combine diagnostic imaging and therapeutic capabilities in a single platform, enhancing targeted treatment and monitoring. Surface coatings are essential for stabilizing MNPs, improving biocompatibility, and preventing oxidation that could compromise their functionality. Natural rubber latex (NRL) offers a promising coating alternative due to its biocompatibility and stability-enhancing properties. While NRL-coated MNPs have shown potential in applications such as magnetic resonance imaging, their effectiveness in theranostics, particularly magnetic hyperthermia (MH) and photoacoustic imaging (PAI), remains underexplored.

methodsIn this study, iron oxide nanoparticles were synthesized via coprecipitation, using NRL as the coating agent. The samples were labeled by NRL amount used during synthesis: NRL-100 for 100 μL and NRL-400 for 400 μL.

resultsCharacterization results showed that NRL-100 and NRL-400 samples exhibited improved stability with zeta potentials of -27 mV and -30 mV, respectively and higher saturation magnetization values of 79 emu/g and 88 emu/g of Fe

conclusionsOverall, NRL-coated MNPs showed great promise as contrast agents in MMUS and PAI imaging, as well as in MH applications.

Indexed as

magnetic hyperthermiamagnetic nanoparticlesmagnetomotive ultrasoundnatural rubber latexphotoacoustic imagingtheranosticsultrasound

Identifiers

PMID39598597
PMCPMC11597301

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.