Evidence map›Paper›PMID 39598580›Full record

ReviewPharmaceutics2024

Optimization Processes of Clinical Chelation-Based Radiopharmaceuticals for Pathway-Directed Targeted Radionuclide Therapy in Oncology.

Katsumi Tomiyoshi, Lydia J Wilson, Firas Mourtada, Jennifer Sims Mourtada, Yuta Namiki, Wataru Kamata, David J Yang, Tomio Inoue

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Targeted Radionuclide Therapy: Current Landscape and Combination Approaches to Improve Oncology Outcomes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katsumi TomiyoshiShonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan.
Lydia J WilsonDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Firas MourtadaDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Jennifer Sims MourtadaHelen F. Graham Cancer Center & Research Institute, Newark, DE 19713, USA.ORCID 0000-0003-1602-4560
Yuta NamikiAdvanced Medical Center, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan.
Wataru KamataAdvanced Medical Center, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan.ORCID 0000-0001-5887-6097
David J YangAdvanced Medical Center, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan.
Tomio InoueAdvanced Medical Center, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan.

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Claudio Guillermo Giraudo · 1995 to 2026
$94.8M
Grant-in-Aid for Scientific Research Basic Research (C) 21K07584NCI NIH HHS P30 CA056036
6 · The paper itself

Abstract

Targeted radionuclide therapy (TRT) for internal pathway-directed treatment is a game changer for precision medicine. TRT improves tumor control while minimizing damage to healthy tissue and extends the survival for patients with cancer. The application of theranostic-paired TRT along with cellular phenotype and genotype correlative analysis has the potential for malignant disease management. Chelation chemistry is essential for the development of theranostic-paired radiopharmaceuticals for TRT. Among image-guided TRT,

Indexed as

177Lu225Acchelationdosimetryimagingtheranostics

Identifiers

PMID39598580
PMCPMC11597032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.