ArticlePharmaceutics2024
Pharmacometabolomics Approach to Explore Pharmacokinetic Variation and Clinical Characteristics of a Single Dose of Desvenlafaxine in Healthy Volunteers.
Anne Michelli Reis Silveira, Salvador Sánchez-Vinces, Alex Ap Rosini Silva, Karen Sánchez-Luquez, Pedro Henrique Dias Garcia, Caroline de Moura Garcia, Rhubia Bethania Socorro Lemos de Brito, Ana Lais Vieira, Lucas Miguel de Carvalho, Marcia Ap Antonio and 1 more
Abstract read
In one paragraphArticle in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Anne Michelli Reis SilveiraHealth Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.
Salvador Sánchez-VincesHealth Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.ORCID 0000-0001-7041-6544 Alex Ap Rosini SilvaHealth Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.ORCID 0000-0002-6400-5201 Karen Sánchez-LuquezHealth Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.
Pedro Henrique Dias GarciaHealth Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.
Caroline de Moura GarciaAlthaia S.A. Indústria Farmacêutica, Atibaia 12952-820, SP, Brazil.
Rhubia Bethania Socorro Lemos de BritoAlthaia S.A. Indústria Farmacêutica, Atibaia 12952-820, SP, Brazil.
Ana Lais VieiraAlthaia S.A. Indústria Farmacêutica, Atibaia 12952-820, SP, Brazil.
Lucas Miguel de CarvalhoHealth Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.ORCID 0000-0002-8766-0452 Marcia Ap AntonioIntegrated Unit of Pharmacology and Gastroenterology (UNIFAG), São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.ORCID 0000-0002-3239-509X Patrícia de Oliveira CarvalhoHealth Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.ORCID 0000-0002-2681-7022 Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 22/04341-6Fundação de Amparo à Pesquisa do Estado de São Paulo 23/11638-8National Council for Scientific and Technological Development 306999/2023-4
6 · The paper itselfAbstract
This study investigated the effects of a single dose of desvenlafaxine via oral administration on the pharmacokinetic parameters and clinical and laboratory characteristics in healthy volunteers using a pharmacometabolomics approach. In order to optimize desvenlafaxine's therapeutic use and minimize potential adverse effects, this knowledge is essential.
Indexed as
desvenlafaxinemetabolic pathwaysmetabolomics profilepharmacokinetics
Identifiers
PMID39598509
PMCPMC11597518
What OpenQuestion holds
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LicenceCC BY
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