Evidence map›Paper›PMID 39598505›Full record

ArticlePharmaceutics2024

Chemical Composition and Bioactivity Dataset Integration to Identify Antiproliferative Compounds in

Luis Diaz, Taylor H Díaz-Herrera, Ericsson Coy-Barrera

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Luis DiazBioprospecting Research Group, School of Engineering, Universidad de La Sabana, Chía 140013, Colombia.ORCID 0000-0002-9588-9935
Taylor H Díaz-HerreraBioorganic Chemistry Laboratory, Universidad Militar Nueva Granada, Cajicá 250247, Colombia.ORCID 0000-0002-1679-5560
Ericsson Coy-BarreraBioorganic Chemistry Laboratory, Universidad Militar Nueva Granada, Cajicá 250247, Colombia.ORCID 0000-0002-3553-9749

Funding

Universidad Militar Nueva Granada EXT-CIAS-3854
6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsThe integration of liquid chromatography-mass spectrometry (LC-MS)-based chemical composition data with antiproliferative activity against three cancer cell lines-PC-3 (prostate adenocarcinoma), SiHa (cervical carcinoma), and A549 (lung carcinoma)-as well as a normal mouse fibroblast line (L929) was performed by covariate analysis. These compounds were subsequently isolated and structurally characterized using spectroscopic methods.

resultsThrough covariate statistics, seven

conclusionsThese findings highlight the potential of

Indexed as

antiproliferative agentsbioactivitycovariate analysislignansPhyllanthus

Identifiers

PMID39598505
PMCPMC11597697

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.