Evidence map›Paper›PMID 39598424›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Adverse Reactions to the Orphan Drug Cerliponase Alfa in the Treatment of Neurolipofuscinosis Type 2 (CLN2).

Ilaria Ammendolia, Maria Sframeli, Emanuela Esposito, Luigi Cardia, Alberto Noto, Mariaconcetta Currò, Gioacchino Calapai, Maria De Pasquale, Carmen Mannucci, Fabrizio Calapai

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Psychiatric manifestations in Neuronal ceroid lipofuscinoses.Orphanet journal of rare diseases · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilaria AmmendoliaDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-4075-8065
Maria SframeliDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Emanuela EspositoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-2663-6387
Luigi CardiaDepartment of Human Pathology of Adult and Childhood "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0000-0002-7286-5674
Alberto NotoDepartment of Human Pathology of Adult and Childhood "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Mariaconcetta CurròDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Gioacchino CalapaiDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98125 Messina, Italy.ORCID 0000-0001-8116-4821
Maria De PasqualeDepartment of Human Pathology of Adult and Childhood "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Carmen MannucciDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98125 Messina, Italy.
Fabrizio CalapaiDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Funding

Pharma-HUB project-HUB for the repositioning of drugs in rare diseases of the nervous system in children CUP J43C22000500006
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adverse reactionscerliponase alfaEudraVigilanceneurolipofuscinosispharmacovigilancepleocytosis

Identifiers

PMID39598424
PMCPMC11597727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.