Evidence map›Paper›PMID 39598162›Full record

ArticleLife (Basel, Switzerland)2024

Chronic Copper Bilysinate Poisoning in Five Texel Sheep: A Case Report.

Dalma Pivariu, Adrian Nechita Oros, Alexandru Tabaran, Francesca Caloni, Pompei Bolfa, Andras-Laszlo Nagy

Abstract readCase Reports
In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dalma PivariuDepartment of Toxicology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania.ORCID 0000-0002-4777-7250
Adrian Nechita OrosDepartment of Toxicology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania.
Alexandru TabaranDepartment of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania.ORCID 0000-0001-5744-0451
Francesca CaloniDepartment of Environmental Science and Policy (ESP), Universita degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy.ORCID 0000-0003-2527-7754
Pompei BolfaDepartment of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre P.O. Box 334, Saint Kitts and Nevis.ORCID 0000-0002-2903-1535
Andras-Laszlo NagyDepartment of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre P.O. Box 334, Saint Kitts and Nevis.ORCID 0000-0002-9596-2899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper is an essential trace element but becomes toxic in overexposed animals. Sheep are the domestic species most prone to chronic copper poisoning, as a slight increase in the dietary concentration can lead to liver accumulation and the development of clinical signs in this species. Common sources of copper in the diet are feed additives and mineral supplements, which are commonly used in pigs and poultry. Recently, new copper supplements were registered for animal nutrition, including copper bilysinate. This study describes an episode of presumed chronic copper poisoning in Five Texel sheep, which were exposed to a compound feed containing copper bilysinate. Four weeks after the introduction of the compound feed into the diet, the first animal started to show typical clinical signs of chronic copper poisoning and died, followed by another animal a week later. Despite removing the compound feed from the diet, a third sheep died 3 weeks later. Two animals survived and fully recovered. Necropsy and histology showed characteristic gross and microscopical lesions typical of copper poisoning. The case report highlights the potential toxic effect of copper bilysinate in sheep.

Indexed as

hemolysispotentially toxic elementtoxicitytrace minerals

Identifiers

PMID39598162
PMCPMC11595775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.