Evidence map›Paper›PMID 39597764›Full record

ArticleMicroorganisms2024

Anthocyanin-Rich Extract Mitigates the Contribution of the Pathobiont Genus

Yannik Zobrist, Michael Doulberis, Luc Biedermann, Gabriel E Leventhal, Gerhard Rogler

Abstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yannik ZobristUniversity of Zurich, 8006 Zurich, Switzerland.ORCID 0009-0009-7898-3178
Michael DoulberisDepartment of Gastroenterology and Hepatology, Department of Medicine, Zurich University Hospital, 8091 Zurich, Switzerland.ORCID 0000-0002-0396-5081
Luc BiedermannDepartment of Gastroenterology and Hepatology, Department of Medicine, Zurich University Hospital, 8091 Zurich, Switzerland.ORCID 0000-0003-0824-4125
Gabriel E LeventhalPharmaBiome AG, 8952 Schlieren, Switzerland.ORCID 0000-0002-4463-166X
Gerhard RoglerDepartment of Gastroenterology and Hepatology, Department of Medicine, Zurich University Hospital, 8091 Zurich, Switzerland.ORCID 0000-0002-1733-9188

Funding

Swiss National Science Foundation 33IC30_166844
6 · The paper itself

Abstract

Anthocyanins (ACs) have been shown to elicit anti-inflammatory and antioxidant effects in animal models of ulcerative colitis (UC). Furthermore, we previously observed in a double-blind randomized trial in UC patients that biochemical disease activity tended to be lower in patients that were exposed to AC. Here, we report on the changes in the fecal microbiome composition in these patients upon AC exposure. UC patients received a 3 g daily dose of an AC-rich bilberry extract (ACRE) for eight weeks. We determined the microbiome composition in longitudinal stool samples from 24 patients and quantified the degree of change over time. We also correlated the relative abundances of individual microbial taxa at different timepoints to fecal concentrations of calprotectin, a proxy for inflammation. Microbiome composition did not change over time as a result of the intervention, in terms of both alpha and beta diversity. However, before the intervention, the abundance of

Indexed as

anthocyanincalprotectinIBDmicrobiomeulcerative colitis

Identifiers

PMID39597764
PMCPMC11596099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.