Evidence map›Paper›PMID 39597628›Full record

ArticleMicroorganisms2024

Evolutionary Analysis and Antiviral Drug Prediction of Mpox Virus.

Zhong-Hao Lian, Chen-Hui Yang, Ye Qiu, Xing-Yi Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhong-Hao LianHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410012, China.
Chen-Hui YangHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410012, China.
Ye QiuHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410012, China.
Xing-Yi GeHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410012, China.ORCID 0000-0003-3964-5140

Funding

Hunan Province 2024RC1028
6 · The paper itself

Abstract

The resurgence of mpox virus (MPXV) poses a significant challenge to global public health. Currently, there is a limited understanding of the evolutionary details of MPXV during its epidemics, and no specific drugs have been developed for it. Herein, analysis of mutations and positive selection sites (PSSs) within the MPXV genomes revealed 799 mutations and 40 PSSs. Visualization analysis indicated that these mutations and PSSs may affect protein structure. Additionally, a protein-protein interaction (PPI) network between human and MPXV was established, identifying 346 MPXV-interacting human proteins (MIHPs). An interaction network involving MIHPs and other viruses confirmed that these proteins can interact with various viruses that infect humans. Functional analysis of MIHPs suggested their enrichment in host immunity pathways. Lastly, two drugs targeting MIHPs and four compounds targeting MPXV proteins were screened as candidate antivirals against MPXV. These findings not only deepen our understanding of MPXV evolution but also aid in the development of anti-MPXV drugs.

Indexed as

alvespimycinimiquimodMIHPMPXVpositive selection

Identifiers

PMID39597628
PMCPMC11596041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.