Evidence map›Paper›PMID 39597537›Full record

ArticleMicroorganisms2024

T-Cell Phenotypes and Systemic Cytokine Profiles of People Living with HIV Admitted to Hospital with COVID-19.

Mieke A van der Mescht, Helen C Steel, Zelda de Beer, Andries Masenge, Fareed Abdullah, Veronica Ueckermann, Ronald Anderson, Theresa M Rossouw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mieke A van der MeschtDepartment of Immunology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Helen C SteelDepartment of Immunology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0001-5899-4472
Zelda de BeerDepartment of Immunology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-2385-889X
Andries MasengeDepartment of Statistics, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0001-8372-2356
Fareed AbdullahDivision for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-1118-9430
Veronica UeckermannDivision for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-4419-3583
Ronald AndersonDepartment of Immunology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-5925-6452
Theresa M RossouwDepartment of Immunology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0003-4066-922X

Funding

South African Medical Research Council SIR
6 · The paper itself

Abstract

Whether SARS-CoV-2 infection leads to a higher mortality and morbidity in people living with HIV (PLWH) in Africa remains inconclusive. In this study, we explored the differences in the T-cell phenotypes between people with and without HIV on the day of admission (V1) and ±7 days later (V2), as well as their cytokine/chemokine profiles on V1. Patients admitted with COVID-19 were recruited between May 2020 and December 2021 from the Steve Biko Academic and Tshwane District Hospitals in Pretoria, South Africa. Of 174 patients, 37 (21%) were PLWH. T-cell profiles were determined by flow cytometry, and cytokine levels were determined using a multiplex suspension bead array. PLWH were significantly younger than those without HIV, and were more likely to be female. In an adjusted analysis, PLWH had higher percentages of CD4+ central memory (CM) programmed cell death protein 1 (PD-1)+, CD8+ effector memory (EM)2, and CD8+ EM4 CD57+ cells, as well as higher concentrations of interleukin (IL)-35 at admission. PLWH with CD4+ T-cell counts of >200 cells/mm

Indexed as

COVID-19cytokinesHIVSARS-CoV-2T-cells

Identifiers

PMID39597537
PMCPMC11596914

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.