ReviewMicroorganisms2024
Epstein-Barr Virus and Human Papillomavirus Coinfection in Colorectal Carcinoma: Systematic Review and Meta-Analysis of the Prevalence.
Review in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Human papillomavirus (HPV) infection and prevalence of colorectal cancer: an updated systematic review and meta-analysis of global data.International journal of surgery (London, England) · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. In addition to known risk factors, oncoviruses have attracted exceptional attention from recent research. Numerous hypotheses on interactions between the Epstein-Barr virus (EBV) and Human papillomavirus (HPV) in CRC are still based on sparse prevalence data of these coinfections. The aim of this study was to perform a comprehensive literature search regarding EBV/HPV coinfection in patients with CRC and to provide its prevalence in the target population. Three electronic databases (PubMed, SCOPUS, and WoS) were searched, and after a double reviewer check, six publications were included in the qualitative and quantitative analyses. This systematic review showed the limited number of studies dealing with the prevalence and role of EBV/HPV coinfection in CRC and the heterogeneity of methodology and reported results. However, in a total of 635 patients, it also showed that the identified 15% EBV/HPV prevalence in CRC (15%, 95% CI: 7-23%) could suggest that further investigations are needed. Histopathologically, all coinfected CRCs were adenocarcinomas, from intermediate to intermediate and high grade, reported across four studies. Increased knowledge about the infectious origin of various cancers, including CRC, has the potential to enhance the vigilance of scientists to design future large-scale multicenter prospective studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.